High functionalization of macrocyclic host compounds based on dynamic octadentate cyclen-metal complexes

合成了一系列基于两个八齿环金属配合物的大三环主体化合物，并将其应用于客体阴离子的内腔识别。双核配合物的分子结构随溶剂、侧链和客体分子的不同而发生动态变化。特别是，首次通过设计复杂的二钠络合物实现了对钠络合物的分子识别。手性双稀土配合物对客体阴离子的手性识别是通过稀土阳离子发射强度的差异来检测的，在某些情况下可以用肉眼来区分。我们还开发了两种新的方法来控制八齿环金属络合物的分子动力学：分子动力学的双峰控制和利用有机反应进行可逆的分子开关。

A series of macrotricyclic host compounds based on two octadentate cyclen-metal complexes was synthesized and applied for the recognition of guest anions using the internal cavity. The dinuclear complexes dynamically changed their molecular structures depending on solvent, side chains, and guest molecules. Especially, molecular recognitions by sodium complex was firstly achieved by using a sophisticatedly designed disodium complex. Chirality recognition of guest anions by chiral di-lanthanoid complexes was detected by the difference of emission intensity of the lanthanoid cations, which can be distinguished by naked eyes in some cases. We also developed two novel methods for the control of molecular dynamics of octadentate cyclen-metal complexes: a bimodal control of molecular dynamics, and reversible molecular switching using organic reactions.