Synthesis and properties of boron containing nucleobases analogues

含硼核碱基类似物的合成及性质

• 批准号: 21750134
• 负责人: ITO Hiroshi
• 金额: $ 2.91万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21750134/
• 关键词: 分子認識; 人工核酸塩基; ヘテロ環; 含ホウ素化合物; 蛍光プローブ; 人口核酸塩基

As isoelectronic analogs of nucleobases, a series of BN-substituted nucleobases were synthesized and fully characterized. The crystallographic and spectroscopic analyses of B(6)-substituted 5-aza-6-borauracils (UBNs) and -thymines (TBNs) revealed that the framework and hydrogen-bonding pattern of the nucleobase analogues were similar to those of the original nucleobase. These "BN-nucleobases" are expected to be applied for novel photo-probes because they showed particular luminescence depended on the substitute on the boron atom.

作为核碱基的等电子类似物，合成了一系列BN取代的核碱基，并对其进行了充分的表征。对B（6）-取代的5-氮杂-6-硼月桂酸（UBN）和-胸腺嘧啶（TBN）的晶体学和光谱学分析表明，其结构和氢键模式与原核碱基相似。这些“BN-碱基”因其在硼原子上的取代而显示出独特的发光特性，有望作为新型光探针应用。

项目成果

Synthesis, Characterization, and Binding Property of Isoelectronic Analogues of Nucleobases, B(6)-Substituted 5-Aza-6-borauracils and -thymines

• DOI: 10.1021/ol1012058
• 发表时间: 2010-08-06
• 期刊: ORGANIC LETTERS
• 影响因子: 5.2
• 作者: Ito, Hiroshi;Yumura, Kyohei;Saigo, Kazuhiko
• 通讯作者: Saigo, Kazuhiko

含ホウ素人工核酸塩基類縁体の合成と機能

含硼人工核碱基类似物的合成和功能

• 发表时间: 2009
• 作者: 伊藤宏;湯村恭平;西郷和彦
• 通讯作者: 西郷和彦