Robust stability of dorsal-ventral patterning by coordination of Chordin and Noggin

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Dorsal-ventral patterning of vertebrates is mainly regulated by two dorsalizing factors, Chordin and Noggin. However, it is not clear why two different proteins, which have the same anti-BMP activity, are needed for D-V axis formation. In the present study, we reveal that Chordin and Noggin show different distribution in the embryo. Having high degradation rate, Chordin proteins form steep gradient, while Noggin proteins, which are very stable, form shallow gradient in vivo. Furthermore, Chordin gradient is properly shaped according to the size of the embryo via Chordin degradation.