Identification and functional analysis of the transcriptonal complex regulating haematopoiesis
Identification and functional analysis of the transcriptonal complex regulating haematopoiesis
批准号:
24790090
负责人:
MURATA Takuya
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
To clarify molecular mechanism of C/EBPa transcriptional regulation in granulopoiesis, we tried to identify transcriptional cofactors of C/EBPa. As a result, we identified poly(ADP-ribose) polymerase-1 (PARP-1) as an interactant of C/EBPa. PARP-1 co-represses C/EBPa transcriptional activity and reduces gene expression of C/EBPa target gene, myeloperoxidase (MPO). Additionally, PARP-1 binds C/EBPa response elements region and colocalizes with C/EBPa there. It is supposed that PARP-1 inhibits C/EBPa binding to response element.
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会议论文
Functional analysis in transcriptional regulation of C/EBPa
C/EBPa转录调控的功能分析
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[村田拓哉, 瀧川遼, 高倉勇気, 野尻久雄]
通讯作者:
野尻久雄
血球分化誘導転写因子C/EBPaの転写制御におけるPARP1の機能解析
PARP1在血细胞分化诱导转录因子C/EBPα转录调控中的功能分析
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[村田拓哉, 瀧川遼, 高倉勇気, 野尻久雄, 村田拓哉]
通讯作者:
村田拓哉
Regulations of oxytocin receptor expression and estrogen action
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批准号:21590253
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2009
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负责人:MURATA Takuya
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依托单位:
Studies in several central effects of oxytocin in lactating rats
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批准号:15590205
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
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财政年份:2003
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负责人:MURATA Takuya
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依托单位:
海外基金