Pharmaceutical development of functional food components based on pharmacokinetic properties

近年来，由于老年人在人口中所占比例的增加和生活方式疾病患者的增加，预防医学和抗衰老医学受到了广泛关注。本文对功能性食品成分叶黄素的吸收机制进行了详细的研究。依折麦布是NPC 1 L1（Niemann-Pick C1-Like 1）的抑制剂，可抑制Caco-2细胞单层中高达40%的叶黄素蓄积。我们的研究结果表明，叶黄素的吸收，至少部分，内流转运蛋白NPC 1 L1介导的。然后我们制备了一些乳剂并研究了其对吸收的改善作用.我们的研究表明，胆汁和乳液配方是必不可少的辅酶Q10（CoQ 10），亲脂性食品成分的吸收。高亲脂性化合物如CoQ 10将扩散未搅拌的水层，并且通过含有具有高HLB（非亲脂平衡）值的表面活性剂的乳液将容易地进入肠顶端膜。

Preventive medicine and anti-aging medicine have received much attention recently due to increases in the proportion of elderly people in the population and patients with lifestyle diseases. We investigated the absorption mechanism of lutein, a functional food component, in detail. Ezetimibe, an inhibitor of NPC1L1 (Niemann-Pick C1-Like 1), inhibited up to 40% of lutein accumulation by Caco-2 cell monolayers. Our results showed that lutein absorption is, at least in part, mediated by influx transporter NPC1L1. We then prepared some emulsions and investigated the effect the improvement the absorption. Our study suggests that Bile and emulsion formulation are essential for absorption of Coenzyme Q10 (CoQ10), a lipophilic food component. Highly lipophilic compounds like CoQ10 would diffuse the unstirred water layer and would easily access the intestinal apical membrane by an emulsion containing a surfactant with a high HLB (hydrophile lipophile balance)value.