The role of phosphoinositide metabolism in the interaction of different cell types in skin and tumor
The role of phosphoinositide metabolism in the interaction of different cell types in skin and tumor
批准号:
24790295
负责人:
NAKAMURA Yoshikazu
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
The interaction of different cell types is important in the maintenance of skin functions. We found that epidermal loss of phospholipase c (PLC) delta1 upregulated interleukin-23 and generated partially similar environment to tumor microenvironment. We also found that subcutaneous injection of B16-F10 cells into keratinocyte-specific PLC delta1 knockout mice enhanced the growth and metastasis of B16-F10 cells.
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表皮におけるホスホリパーゼCδ1の欠損は血清中のIL-17濃度を上昇させ顆粒球増多を引き起こす
表皮中磷脂酶 Cδ1 缺乏会增加血清 IL-17 浓度并导致粒细胞增多
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[大山峻幸、杉山和靖, 他2名, Kaori Kanemaru, Kaori Kanemaru, 金丸 佳織, Kaori Kanemaru, 金丸 佳織]
通讯作者:
金丸 佳織
Phospholipase Cδ1 Regulates Keratinocyte Proliferation and differentiation
磷脂酶 Cδ1 调节角质形成细胞增殖和分化
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[1. Ogura, T., Kanemaru, K., Nakamura, Y., and Fukami, K]
通讯作者:
K
Epidermal phospholipase Cδ1 regulates systemic interleukin-17 levels and granulocyte counts in mice
表皮磷脂酶 Cδ1 调节小鼠全身白细胞介素 17 水平和粒细胞计数
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Kanemaru, K., Nakamura, Y., and Fukami, K.]
通讯作者:
K.
ホスホリパーゼCδ1はケラチノサイトの増殖・分化を制御する
磷脂酶 Cδ1 控制角质形成细胞增殖和分化
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[5.岡臨, 小倉崇寛, 金丸佳織, 中村由和, 深見希代子]
通讯作者:
深見希代子
Keratinocyte-specific loss of Phospholipase Cδ1 results in aberrant activation of IL-23/IL-17 axis and skin inflammation
角质形成细胞特异性磷脂酶 Cδ1 缺失导致 IL-23/IL-17 轴异常激活和皮肤炎症
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Nakamura, Y., Kanemaru, K., and Fukami, K]
通讯作者:
K
共 27 条
Roles of phospholipase C deltal in hair shaft formation
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批准号:21790292
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
-
财政年份:2009
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负责人:NAKAMURA Yoshikazu
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依托单位:
Sequence Complementarity -Independence Functional RNAs
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批准号:18107005
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$72.38万
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财政年份:2006
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负责人:NAKAMURA Yoshikazu
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依托单位:
Structural and functional study of translation apparatus from the viewpoint of molecular mimicry and prion transmission
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批准号:14035207
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$83.78万
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财政年份:2002
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负责人:NAKAMURA Yoshikazu
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依托单位:
Structural and functional study of translational release factor from the viewpoint of molecular mimicry and prion transmission
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批准号:13308040
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$29.45万
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财政年份:2001
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负责人:NAKAMURA Yoshikazu
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依托单位:
Spatiotemporal Network of RNA Information Flow
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批准号:13051101
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$208.19万
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财政年份:2001
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负责人:NAKAMURA Yoshikazu
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依托单位:
Drug discovery and design based on molecular mimicry
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批准号:11557190
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.58万
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财政年份:1999
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负责人:NAKAMURA Yoshikazu
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依托单位:
Molecular Mimicry in Translation
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批准号:11694195
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项目类别:Grant-in-Aid for Scientific Research (A).
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资助金额:$14.27万
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财政年份:1999
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负责人:NAKAMURA Yoshikazu
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依托单位:
Molecular basis of RNA function
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批准号:09278102
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas (A)
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资助金额:$132.1万
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财政年份:1997
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负责人:NAKAMURA Yoshikazu
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依托单位:
Regulation of Translation Termination
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批准号:08044196
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$22.85万
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财政年份:1996
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负责人:NAKAMURA Yoshikazu
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依托单位:
Study of Pneumocystis carinii : from Molecular Microbiology to Drug Discovery
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批准号:07557027
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$13.44万
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财政年份:1995
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负责人:NAKAMURA Yoshikazu
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依托单位:
PHILOLOGICAL STUDY ON RELIGIOUS MOMENTS IN OLD RUSSIAN AND EARLY MODERN RUSSIAN LITERATURE
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批准号:06301053
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$4.35万
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财政年份:1994
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负责人:NAKAMURA Yoshikazu
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依托单位:
Post-Transcriptional Control of Gene Expression : mRNA Degradation and Translational Regulation
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批准号:04044052
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$19.2万
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财政年份:1992
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负责人:NAKAMURA Yoshikazu
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依托单位:
Role of Russian-Slavic Culture in Japanese Modernization
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批准号:02301067
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项目类别:Grant-in-Aid for Co-operative Research (A)
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资助金额:$4.93万
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财政年份:1990
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负责人:NAKAMURA Yoshikazu
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依托单位:
Molecular Biology of Pneumocystis Carinii and its Clinical Application
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批准号:02454175
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.97万
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财政年份:1990
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负责人:NAKAMURA Yoshikazu
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依托单位:
Synthetic Studies on Russian and East European View on Japan and its Chages
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批准号:63301064
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项目类别:Grant-in-Aid for Co-operative Research (A)
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资助金额:$4.1万
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财政年份:1988
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负责人:NAKAMURA Yoshikazu
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依托单位:
海外基金