Sequence Complementarity -Independence Functional RNAs
Sequence Complementarity -Independence Functional RNAs
批准号:
18107005
负责人:
NAKAMURA Yoshikazu
金额:
$72.38万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2010
中文摘要
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英文摘要
Functional RNAs are classified into two types : one, like antisense and microRNA, those function with the sequence complementarity to the target mRNA or DNA, while the other, like aptamer, those function independent of the sequence complementarity. In this study, we clarified superior potential of the latter class RNA that exhibits conformational plasticity by : 1) creating artificial aptamers to target proteins of therapeutic interest ; and 2)uncover the natural aptamers encoded in human genome.
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Selection of RNA aptamers against recombinant transforming growth factor-beta type III receptor displayed on cell surface.
针对细胞表面展示的重组转化生长因子-β III 型受体的 RNA 适配体的选择。
DOI:
--
发表时间:
2006
期刊:
Biochimie 88
影响因子:
--
作者:
[Ohuchi, S.P., Ohtsu, T., Nakamura, Y.]
通讯作者:
Y.
構造体として機能するRNA
RNA作为结构的功能
DOI:
--
发表时间:
2006
期刊:
実験医学 24
影响因子:
--
作者:
[Asakura, T., Nakazawa, Y., 大内将司]
通讯作者:
大内将司
RNAは擬態する
RNA模拟物
DOI:
--
发表时间:
2006
期刊:
科学 76
影响因子:
--
作者:
[Jun-ya Shoji, Takashi Kikuma, Manabu Arioka, and Katsuhiko Kitamoto, 朝倉哲郎(分担), 中村義一]
通讯作者:
中村義一
アプタマー創薬
适体药物发现
DOI:
--
发表时间:
2006
期刊:
ファルマシア 42
影响因子:
--
作者:
[藤原将寿, 宮川伸, 中村義一]
通讯作者:
中村義一
A systematic evaluation of the function of the protein-remodeling factor Hsp104 in [PSI^+] prion propagation in S.
系统评价蛋白质重塑因子 Hsp104 在 [PSI^] 朊病毒在 S.
DOI:
--
发表时间:
2007
期刊:
cerevisiae by comprehensive chromosomal mutations. Prion 1
影响因子:
--
作者:
[Takahashi, A., Hara, H., Kurahashi, H., Nakamura, Y.]
通讯作者:
Y.
共 101 条
The role of phosphoinositide metabolism in the interaction of different cell types in skin and tumor
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批准号:24790295
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.83万
-
财政年份:2012
-
负责人:NAKAMURA Yoshikazu
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依托单位:
Roles of phospholipase C deltal in hair shaft formation
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批准号:21790292
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2009
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负责人:NAKAMURA Yoshikazu
-
依托单位:
Structural and functional study of translation apparatus from the viewpoint of molecular mimicry and prion transmission
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批准号:14035207
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$83.78万
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财政年份:2002
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负责人:NAKAMURA Yoshikazu
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依托单位:
Structural and functional study of translational release factor from the viewpoint of molecular mimicry and prion transmission
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批准号:13308040
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$29.45万
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财政年份:2001
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负责人:NAKAMURA Yoshikazu
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依托单位:
Spatiotemporal Network of RNA Information Flow
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批准号:13051101
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$208.19万
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财政年份:2001
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负责人:NAKAMURA Yoshikazu
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依托单位:
Drug discovery and design based on molecular mimicry
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批准号:11557190
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.58万
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财政年份:1999
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负责人:NAKAMURA Yoshikazu
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依托单位:
Molecular Mimicry in Translation
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批准号:11694195
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项目类别:Grant-in-Aid for Scientific Research (A).
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资助金额:$14.27万
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财政年份:1999
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负责人:NAKAMURA Yoshikazu
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依托单位:
Molecular basis of RNA function
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批准号:09278102
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas (A)
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资助金额:$132.1万
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财政年份:1997
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负责人:NAKAMURA Yoshikazu
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依托单位:
Regulation of Translation Termination
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批准号:08044196
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$22.85万
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财政年份:1996
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负责人:NAKAMURA Yoshikazu
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依托单位:
Study of Pneumocystis carinii : from Molecular Microbiology to Drug Discovery
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批准号:07557027
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$13.44万
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财政年份:1995
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负责人:NAKAMURA Yoshikazu
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依托单位:
PHILOLOGICAL STUDY ON RELIGIOUS MOMENTS IN OLD RUSSIAN AND EARLY MODERN RUSSIAN LITERATURE
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批准号:06301053
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$4.35万
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财政年份:1994
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负责人:NAKAMURA Yoshikazu
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依托单位:
Post-Transcriptional Control of Gene Expression : mRNA Degradation and Translational Regulation
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批准号:04044052
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$19.2万
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财政年份:1992
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负责人:NAKAMURA Yoshikazu
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依托单位:
Role of Russian-Slavic Culture in Japanese Modernization
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批准号:02301067
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项目类别:Grant-in-Aid for Co-operative Research (A)
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资助金额:$4.93万
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财政年份:1990
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负责人:NAKAMURA Yoshikazu
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依托单位:
Molecular Biology of Pneumocystis Carinii and its Clinical Application
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批准号:02454175
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.97万
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财政年份:1990
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负责人:NAKAMURA Yoshikazu
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依托单位:
Synthetic Studies on Russian and East European View on Japan and its Chages
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批准号:63301064
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项目类别:Grant-in-Aid for Co-operative Research (A)
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资助金额:$4.1万
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财政年份:1988
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负责人:NAKAMURA Yoshikazu
-
依托单位:
海外基金