pathophysiological analysis of autophagic substrate Nbr1.

为了研究Nbr1代谢的生理机制、Nbr1的蓄积及其对肝脏的影响，我们建立了肝脏特异的ATG7和Nbr1双缺陷小鼠，并进行了生化和形态学分析。ATG7和Nbr1在肝脏中的同时丢失会导致肝脏肿大和肝功能障碍。结果表明，在ATG7缺陷的肝脏中，Nbr1的缺失对肝脏的病理影响很小，还需要进一步的分析来阐明Nbr1在ATG7-p62双基因敲除组织中的病理生理作用。

To investigate a physiology of the Nbr1 metabolism, accumulation of Nbr1 and the affect to the liver, we created liver specific Atg7 and Nbr1-double deficient mice, and performed biochemical and morphological analysis.In liver specific Nbr1 knockout mice, the abnormality is not recognized. Simultaneous loss of Atg7 and Nbr1 in the liver cause hepatomegaly and liver dysfunction. It is shown that Loss of Nbr1 has few impacts on liver pathology in Atg7-deficient livers.Further analysis is needed to clarify the pathophysiological role of Nbr1 in Atg7-p62 double knockout tissues.