Establishment of multidrug-resistant bacteria using laboratory automation and analysis of their evolution processes
Establishment of multidrug-resistant bacteria using laboratory automation and analysis of their evolution processes
批准号:
24700305
负责人:
SUZUKI Shingo
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
Emergence and spread of bacteria exhibiting resistance to multidrug have become serious problems. Analysis of evolution process of multidrug-resistance using experimental evolution revealed that multidrug-resistant bacteria showed cross-resistance and hypersensitivity to other classes of antibiotics. In this study, whole-genome resequencing of resistant bacteria revealed the molecular mechanism underlying hypersensitivity and combination of two antibiotics showing hypersensitivity to each other could prevent the development of antibiotic resistance.
期刊论文(0)
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会议论文
全自動実験室進化システムの構築と大腸菌の多系列・多種ストレス環境下での実験室進化
全自动实验室进化系统构建及多菌株、多应激环境下大肠杆菌实验室进化
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[Yotsumoto, Y., 古澤力, 木賀大介, 堀之内貴明,源晃明,鈴木真吾,清水浩,古澤力]
通讯作者:
堀之内貴明,源晃明,鈴木真吾,清水浩,古澤力
独立行政法人理化学研究所生命 システム研究センター 多階層生命動態研究チーム
RIKEN生命系统研究中心多级生命动力学研究小组
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
実験室進化を用いた大腸菌の抗生物質耐性獲得ダイナミクスの解析Laboratory evolution of antibiotic resistant Escherichia coli
抗生素耐药性大肠杆菌的实验室进化
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[山元大輔, 佐藤耕世, 堀之内貴明,源晃明,鈴木真吾,清水浩,古澤力, 鈴木真吾,堀之内貴明,古澤力]
通讯作者:
鈴木真吾,堀之内貴明,古澤力
Construction of a Comprehensive Database of the Series of Rhyme Dictionaries "Qieyun".
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批准号:16K02671
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2016
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负责人:SUZUKI Shingo
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依托单位:
Constructing Databases for the Study of the Lost-texts of the Rime Dictionary "Qieyun"
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批准号:24720178
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2012
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负责人:SUZUKI Shingo
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依托单位:
Effect of early life stress on BDNF-mediated lipid homeostasis
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批准号:24791111
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2012
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负责人:SUZUKI Shingo
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依托单位:
Exome sequencing of drug-metabolizing enzyme and transporter (DMET) genes and immune related genes in cynomolgus macaque.
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批准号:23500503
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2011
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负责人:SUZUKI Shingo
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依托单位:
Cholesterol metabolite-dependent regulation of synaptic development
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批准号:22700393
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.33万
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财政年份:2010
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负责人:SUZUKI Shingo
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依托单位:
海外基金