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Effect of early life stress on BDNF-mediated lipid homeostasis

Effect of early life stress on BDNF-mediated lipid homeostasis
早期生活压力对 BDNF 介导的脂质稳态的影响
批准号：
24791111
负责人：
SUZUKI Shingo
金额：
$2.75万
依托单位：
Kagawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2012
资助国家：
日本
项目状态：
已结题
起止时间：
2012-04-01 至 2014-03-31
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791111/
关键词：
BDNFコレステロール母子分離パルミトイル酸母子分離モデルパルミトレイン酸神経細胞発達シナプス

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英文摘要
Brain-derived neurotrophic factor (BDNF) mediates neuronal cholesterol biosynthesis during synapse development. However the effect of early life stress on the BDNF-dependent lipid homeostasis in neurons is not well understood. Thus, we here investigated the crosstalk between stress and BDNF signaling. First, it was shown that cholesterol biosynthesis in neurons were not affected by the treatment with corticosterone while stress hormones were known to inhibit cholesterol biosynthetic pathway in non-neuronal cells. Second, we found that maternal deprivation reduced the expression of cholesterol biosynthetic enzymes. These results indicated a possibility that early life stress influenced BDNF-mediated cholesterol biosynthesis by decreasing their expression.
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Immunohistochemical analysis of steroidogenic acute regulatory protein (StAR) and StAR-binding protein (SBP) expressions in the testes of mice during fetal development.
DOI： 10.1016/j.repbio.2013.01.172
发表时间： 2013-03
期刊： Reproductive biology
影响因子： 2.1
作者： [K. Warita;T. Mitsuhashi;Shiho Fukui;Ken-ichi Ohta;Shingo Suzuki;T. Miki;Y. Takeuchi;T. Yokoyama;H. Kitagawa;T. Sugawara;N. Hoshi]
通讯作者： K. Warita;T. Mitsuhashi;Shiho Fukui;Ken-ichi Ohta;Shingo Suzuki;T. Miki;Y. Takeuchi;T. Yokoyama;H. Kitagawa;T. Sugawara;N. Hoshi
Early postnatal maternal separation causes alterations in the expression ofβ3-adrenergic receptor in rat adipose tissue suggesting long-term influence on obesity
产后早期母体分离导致大鼠脂肪组织中β3肾上腺素受体表达的改变，表明对肥胖的长期影响
DOI： 10.1016/j.bbrc.2013.11.005
发表时间： 2013
期刊： Biochem Biophys Res Commun
影响因子： --
作者： [Miki T, Liu JQ, Ohta K, Suzuki S, Kusaka T, Warita K, Yokoyama T, Jamal M, Ueki M, Yakura T, Tamai M, Sumitani K, Hosomi N, Takeuchi Y]
通讯作者： Takeuchi Y
Morphological evidence of an altered process of synaptic transcytosis in adult rats exposed to ethanol.
暴露于乙醇的成年大鼠突触转胞吞作用改变过程的形态学证据。
DOI： --
发表时间： 2012
期刊： Alcohol and Alcoholism
影响因子： 2.8
作者： [Y. Takeuchi, T. Miki, Jun, Ken, K. Warita, Y. Matsumoto, Shingo Suzuki, Motoki Tamai, K. Ameno, K. Bedi, Tomiko Yakura]
通讯作者： Tomiko Yakura
Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks.
脑源性神经营养因子表达的升高有利于雏鸡的视觉印记。
DOI： 10.1111/jnc.12039
发表时间： 2012
期刊： Journal of Neurochemistry
影响因子： 4.7
作者： [浜崎　浩子, 前川文彦, Tomoharu Nakamori, Fumihiko Maekawa, 浜崎　浩子, Keiko Suzuki]
通讯作者： Keiko Suzuki
共 17 条
    Construction of a Comprehensive Database of the Series of Rhyme Dictionaries "Qieyun".
    • 批准号：
      16K02671
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.83万
    • 财政年份：
      2016
    • 负责人：
      SUZUKI Shingo
    • 依托单位：
      Osaka University
    Constructing Databases for the Study of the Lost-texts of the Rime Dictionary "Qieyun"
    • 批准号：
      24720178
    • 项目类别：
      Grant-in-Aid for Young Scientists (B)
    • 资助金额：
      $2.66万
    • 财政年份：
      2012
    • 负责人：
      SUZUKI Shingo
    • 依托单位：
      Osaka University
    Establishment of multidrug-resistant bacteria using laboratory automation and analysis of their evolution processes
    Exome sequencing of drug-metabolizing enzyme and transporter (DMET) genes and immune related genes in cynomolgus macaque.
    • 批准号：
      23500503
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.49万
    • 财政年份：
      2011
    • 负责人：
      SUZUKI Shingo
    • 依托单位：
      Tokai University
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