Effect of early life stress on BDNF-mediated lipid homeostasis

早期生活压力对 BDNF 介导的脂质稳态的影响

• 批准号: 24791111
• 负责人: SUZUKI Shingo
• 金额: $ 2.75万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791111/
• 关键词: BDNF; コレステロール; 母子分離; パルミトイル酸; 母子分離モデル; パルミトレイン酸; 神経細胞; 発達; シナプス

Brain-derived neurotrophic factor (BDNF) mediates neuronal cholesterol biosynthesis during synapse development. However the effect of early life stress on the BDNF-dependent lipid homeostasis in neurons is not well understood. Thus, we here investigated the crosstalk between stress and BDNF signaling. First, it was shown that cholesterol biosynthesis in neurons were not affected by the treatment with corticosterone while stress hormones were known to inhibit cholesterol biosynthetic pathway in non-neuronal cells. Second, we found that maternal deprivation reduced the expression of cholesterol biosynthetic enzymes. These results indicated a possibility that early life stress influenced BDNF-mediated cholesterol biosynthesis by decreasing their expression.

脑源性神经营养因子(BDNF)在突触发育过程中介导神经元胆固醇的生物合成。然而，早期生活应激对BDNF依赖的神经元脂质稳态的影响还不是很清楚。因此，我们在这里研究了胁迫和BDNF信号之间的串扰。首先，研究表明，皮质酮不影响神经元中胆固醇的生物合成，而应激激素可以抑制非神经元细胞中胆固醇的生物合成途径。其次，我们发现，母亲的剥夺减少了胆固醇生物合成酶的表达。这些结果表明，早期生活应激可能通过减少BDNF介导的胆固醇的表达来影响其生物合成。

项目成果

Immunohistochemical analysis of steroidogenic acute regulatory protein (StAR) and StAR-binding protein (SBP) expressions in the testes of mice during fetal development.

• DOI: 10.1016/j.repbio.2013.01.172
• 发表时间: 2013-03
• 期刊: Reproductive biology
• 影响因子: 2.1
• 作者: K. Warita;T. Mitsuhashi;Shiho Fukui;Ken-ichi Ohta;Shingo Suzuki;T. Miki;Y. Takeuchi;T. Yokoyama;H. Kitagawa;T. Sugawara;N. Hoshi

Early postnatal maternal separation causes alterations in the expression ofβ3-adrenergic receptor in rat adipose tissue suggesting long-term influence on obesity

产后早期母体分离导致大鼠脂肪组织中β3肾上腺素受体表达的改变，表明对肥胖的长期影响

• DOI: 10.1016/j.bbrc.2013.11.005
• 发表时间: 2013
• 期刊: Biochem Biophys Res Commun
• 作者: Miki T;Liu JQ;Ohta K;Suzuki S;Kusaka T;Warita K;Yokoyama T;Jamal M;Ueki M;Yakura T;Tamai M;Sumitani K;Hosomi N;Takeuchi Y
• 通讯作者: Takeuchi Y

Morphological evidence of an altered process of synaptic transcytosis in adult rats exposed to ethanol.

暴露于乙醇的成年大鼠突触转胞吞作用改变过程的形态学证据。

• 发表时间: 2012
• 期刊: Alcohol and Alcoholism
• 影响因子: 2.8
• 作者: Y. Takeuchi;T. Miki;Jun;Ken;K. Warita;Y. Matsumoto;Shingo Suzuki;Motoki Tamai;K. Ameno;K. Bedi;Tomiko Yakura
• 通讯作者: Tomiko Yakura

Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks.

脑源性神经营养因子表达的升高有利于雏鸡的视觉印记。

• DOI: 10.1111/jnc.12039
• 发表时间: 2012
• 期刊: Journal of Neurochemistry
• 影响因子: 4.7
• 作者: 浜崎 浩子;前川文彦;Tomoharu Nakamori;Fumihiko Maekawa;浜崎 浩子;Keiko Suzuki
• 通讯作者: Keiko Suzuki

Short-term ethanol exposure causes imbalanced neurotrophic factor allocation in the basal forebrain cholinergic system: a novel insight into understanding the initial processes of alcohol addiction.

短期乙醇暴露导致基底前脑胆碱能系统神经营养因子分配失衡：了解酒精成瘾初始过程的新见解。

• DOI: 10.1007/s00702-013-1085-y
• 发表时间: 2014
• 期刊: J Neural Transm.
• 作者: Miki T;Kusaka T;Yokoyama T;Ohta K;Suzuki S;Warita K;Jamal M;Wang ZY;Ueki M;Liu JQ;Yakura T;Tamai M;Sumitani K;Hosomi N;Takeuchi Y.
• 通讯作者: Takeuchi Y.