development of hepatocellular carcinoma novel therapeutics that target wnt signaling and dUTPase

具有dUTPase抑制作用的药物的例子被鉴定为中药紫荆a β - hiv的一个成分。创造出类似hiv的化合物，证实有抑制肝癌细胞生长的作用。我发现dUTPase和EpCAM的表达呈正相关。在抑制β -连环蛋白表达时，观察到dUTpase启动子活性降低，发现dUTpase的表达可能在Wnt信号传导中受到调控，dUTpase的强表达激活Wnt信号传导。EpCAM与Wnt / β -连环蛋白信号通路明显相关，并以dUTPase为抑制剂，鉴定出dUTPase，生成与β - hiv相似的化合物。

Examples of drugs having dUTPase inhibitory effect was identified as a component of the Chinese herb Lithospermum a beta-HIVS. Create a similar compound of HIVS, it was confirmed liver cancer cell growth inhibitory effect. I have revealed a positive correlation of expression of dUTPase and EpCAM. In suppression of the expression of beta-catenin, the observed decrease in activity dUTpase promoter, expression of dUTPase found the possibility of being regulated in Wnt signaling, a strong expression of dUTPase activation of Wnt signaling.The apparent correlation of EpCAM and Wnt / beta-catenin signaling and dUTPase, dUTPase as inhibitors, were identified, create a beta-HIVS similar compounds.