Single Molecules: From Observation to Manipulation

单分子：从观察到操纵

• 批准号: 5428427
• 负责人: Professor Dr. Peter Hänggi
• 金额: --
• 依托单位: School of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2004
• 资助国家: 德国
• 起止时间: 2003-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5428427?language=en
• 关键词: Single; Molecules; Observation; Manipulation

This proposal deals with three aspects related to the physics, chemistry and biology of single molecules, covering the range from observation methods to manipulation. In the theoretical and computational research program outlined in this proposal we plan to first investigate the dynamics of molecular unbinding (rupture) processes, confronting our results and predictions with dynamic force spectroscopy experiments. The insight gained in the rupture force studies will be transferred further to the problem of manipulating molecules at interfaces. Here the "pick-up-and-put-down" method will be investigated in detail, focusing on the contact between an approaching atomic force microscope (AFM)-tip and surface molecules. This manipulation by close proximity is then replaced by a remote control idea where molecular "engines" are fuelled and controlled by light. These light-driven molecular engines can be directed around at will and perform as well corresponding work. The proposed program is expected to stimulate new experiments in order to study and control the dynamics of single molecules; moreover, it will improve and optimize the various control schemas on the nanoscale.

该提案涉及与单分子的物理、化学和生物学相关的三个方面，涵盖了从观察方法到操纵的范围。在本提案中概述的理论和计算研究计划中，我们计划首先研究分子解束缚（断裂）过程的动力学，用动态力谱实验对抗我们的结果和预测。在断裂力研究中获得的见解将进一步转移到界面处操纵分子的问题上。在这里，“拿起和放下”的方法将详细研究，专注于接近原子力显微镜（AFM）的尖端和表面分子之间的接触。这种近距离的操纵随后被远程控制思想所取代，在远程控制思想中，分子“引擎”由光驱动和控制。这些光驱动的分子发动机可以随意引导，并执行相应的工作。该计划预计将刺激新的实验，以研究和控制单分子的动力学;此外，它将改善和优化纳米尺度上的各种控制方案。