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体内環境下における最先端人工関節材料のビーリングスの分光学的・力学的評価

对身体环境中最先进的人工关节材料 Bealings 进行光谱和机械评估

基本信息

批准号：
14F04783
负责人：
PEZZOTTI G.
金额：
$ 1.47万
依托单位：
Kyoto Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2014
资助国家：
日本
起止时间：
2014-04-25 至 2017-03-31
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14F04783/
关键词：
tribology biomaterials ceramics prosthetic implants osteointegration lubrication metal staining silicon nitride BIOCERAMICS BIOINERTNESS HIP JOINT WEAR RAMAN SPECTRA

项目摘要

This research project provided a further insight on the durability of various ceramic biomaterials applied in orthopaedic prosthetic implants both in-vitro and in-vivo. Simulated wear testing and retrieved materials analysis clearly showed that most commonly applied ceramic biomaterials (monolithic alumina, zirconia and zirconia toughened alumina) degrade in-vivo at a rhythm which is significantly higher when compared to conventional laboratory simulations. It was also shown that metal staining caused by dislocation of the implant, leads to an even faster degradation. The presence of lubrication limits the severity of the tribological contact reducing the friction coefficient but might promote the transformation of tetragonal zirconia into monoclinic, reducing the mechanical properties of the implant. The concept of bioinert biomaterials has then been questioned: even oxides, which are extremely stable from a chemical point of view, have a clear and unexpected interaction with the human body environment. Taking into account these results, silicon nitride has been introduced as an alternative biomaterial. Studies conducted in-vitro clearly showed that Si3N4 positively interact with the human body environment and can thus be successfully used for different applications, from promotion of bone growth and osteointegration (e.g.: in spinal implants or bone fillers) to wear resistance (e.g.: in femoral heads for hip implants). The additional anti-bacterial effect granted by Si3N4 has never been observed before for other conventional ceramic material used in orthopaedics.

该研究项目提供了对各种陶瓷生物材料在体外和体内应用于骨科假体植入物的耐久性的进一步了解。模拟磨损试验和回收材料分析清楚地表明，最常用的陶瓷生物材料（整体氧化铝、氧化锆和氧化锆增韧氧化铝）在体内降解的节奏明显高于传统的实验室模拟。研究还表明，植入物脱位引起的金属染色导致更快的降解。润滑剂的存在限制了摩擦接触的严重程度，降低了摩擦系数，但可能促进四氧化锆向单斜晶系的转变，降低了植入物的机械性能。生物惰性生物材料的概念随后受到质疑：即使是从化学角度来看极其稳定的氧化物，也会与人体环境发生明显和意想不到的相互作用。考虑到这些结果，氮化硅已被引入作为替代生物材料。在体外进行的研究清楚地表明，Si3N4与人体环境积极相互作用，因此可以成功地用于不同的应用，从促进骨生长和骨整合（例如：在脊柱植入物或骨填充物中）到耐磨性（例如：在用于髋关节植入物的股骨头中）。Si3N4所赋予的额外抗菌效果在用于骨科的其他传统陶瓷材料中从未观察到过。