Molecularly Engineered Biomaterials for Minimally Invasive Dental Treatment

描述（由申请人提供）：用于微创牙科治疗的分子工程生物材料分子工程生物材料是微创牙科准备，龋齿去除和其他牙科治疗的理想候选材料，包括龈周区清洁和其他一般清洁和美白。通过对分子结构的控制，可以定制和优化生物化学和生物力学性能。研究人员建议使用完善的生物化学来创造一类新的牙科材料，用于微创牙科准备，并作为组织修复剂，潜在地装载治疗药物。加工化学将与先进的纳米/微制造技术相结合，以提高第一阶段可行性的成功率。还将对选定的材料进行初步毒性评估。第二阶段将集中在体内的生物力学性能，特别是在牙齿准备和缺陷去除方面。

DESCRIPTION (provided by applicant): Molecularly Engineered Biomaterials for Minimally Invasive Dental Treatment Molecularly-engineered biomaterials are an ideal candidate for minimally invasive dental preparations, caries removal, and other dental treatments, including cleaning in perigingival zone and other general cleaning and whitening. Through the control of molecular structure, the biochemical and biomechanical properties can be tailored and optimized. The investigators propose to use the well- established biochemistry to create a class of new dental materials useful for minimally-invasive dental preparation and useful as tissue repair agents potentially loaded with therapeutics. Processing chemistry is to be integrated with advanced nano/micro-fabrication technology to enhance the success rate of the Phase I feasibility. Preliminary toxicity assessment will also be conducted on selected materials. Phase II will focus on the biomechanical performance in vivo, especially regarding dental preparation and defect removal.