電気機械的結合したマルチスケール大腿モデルの研究開発

经皮电刺激（TES）产生可以产生肌肉收缩的电场。通过这种方式，TES可用于神经肌肉系统的受损功能恢复、治疗和医学诊断测试（神经传导研究）。TES引起的肌肉反应取决于组织的电生理特性。为了改善康复和医疗评估，仿真模型将提供框架来选择刺激参数。在我过去的研究中，目标是使用组织行为的离散模型将组织的电特性与运动神经元激活相结合。该模型用于从宏观上明确组织的几何和电学因素以及电刺激参数对肌肉募集和神经激活的影响。在这一年中，我对模型验证和模拟模型的实验测量进行了改进（在人体组织模型中，电压分布的误差降低到2%）。此外，还包括并验证了肌电图模型，以研究肌肉激活，用于将来诊断神经状况。并将其推广到脑电刺激，设计了一种新型的脑电描记电极。最后，提出了一种新的方法来测量的三维位置的针的肌肉诊断的基础上，我们的计算模型的电压分布，作为神经传导研究的电生理为基础的机器人模拟器的发展的一部分。

Transcutaneous electrical stimulation (TES) generates an electric field that can yield a muscle contraction. In this way, TES can be used for regaining impaired functions, therapy, and medical diagnosis test (nerve conduction study) of the neuromuscular system. The muscle response caused by TES depends on the electrophysiological characteristics of the tissues. To improve rehabilitation and medical evaluation, a simulation model would provide the framework to select the stimulation parameters.In my past research, the objective was to integrate the electrical properties of tissues with the motor neurons activation using a dispersive model of the tissues behavior. This novel model was used to clarify the influence of the geometric and electrical factors of tissues and electrical stimulation parameters in the muscle recruitment and nerve activation at the macro level.During this year, I worked on the refinement of the experimental measurements for model validation and the simulation model (error of the voltage distribution was reduced to 2% in a human tissue-like phantom). Also, an electromyography model was included and validated to investigate muscle activation for future diagnosis of nerve condition. Moreover, the results were extended to brain stimulation, and a new electroencephalography electrode was designed. Finally, a new method was proposed to measure the 3D-position of the needle for muscle diagnosis based on our computation model of the voltage distribution, as part of the development of the electrophysiological based robotic simulator for nerve conduction study.