電気機械的結合したマルチスケール大腿モデルの研究開発

经皮电刺激(TES)产生的电场可以产生肌肉收缩。这样，TES可用于恢复受损的功能、治疗和神经肌肉系统的医学诊断测试(神经传导研究)。TES引起的肌肉反应取决于组织的电生理特性。为了改善康复和医学评估，模拟模型将提供选择刺激参数的框架。在我过去的研究中，目标是使用组织行为的离散模型来整合组织的电特性和运动神经元的激活。这一新的模型被用来阐明组织的几何和电学因素以及电刺激参数在宏观水平上对肌肉招募和神经激活的影响。在这一年里，我致力于对模型验证和仿真模型的实验测量进行精细化(在人体组织状体模中，电压分布的误差减少到2%)。此外，还包括了一个肌电模型，并验证了该模型可用于研究肌肉激活，以用于未来神经状况的诊断。此外，将结果推广到脑刺激，并设计了一种新的脑电电极。最后，作为基于电生理的机器人神经传导模拟器开发的一部分，提出了一种新的基于电压分布计算模型的肌肉诊断针三维位置测量方法。

Transcutaneous electrical stimulation (TES) generates an electric field that can yield a muscle contraction. In this way, TES can be used for regaining impaired functions, therapy, and medical diagnosis test (nerve conduction study) of the neuromuscular system. The muscle response caused by TES depends on the electrophysiological characteristics of the tissues. To improve rehabilitation and medical evaluation, a simulation model would provide the framework to select the stimulation parameters.In my past research, the objective was to integrate the electrical properties of tissues with the motor neurons activation using a dispersive model of the tissues behavior. This novel model was used to clarify the influence of the geometric and electrical factors of tissues and electrical stimulation parameters in the muscle recruitment and nerve activation at the macro level.During this year, I worked on the refinement of the experimental measurements for model validation and the simulation model (error of the voltage distribution was reduced to 2% in a human tissue-like phantom). Also, an electromyography model was included and validated to investigate muscle activation for future diagnosis of nerve condition. Moreover, the results were extended to brain stimulation, and a new electroencephalography electrode was designed. Finally, a new method was proposed to measure the 3D-position of the needle for muscle diagnosis based on our computation model of the voltage distribution, as part of the development of the electrophysiological based robotic simulator for nerve conduction study.