マヌカハニー摂取による大腸がん予防機構の解明に向けたニュートリオミクス研究

今年，我们在去年建立的动物模型中使用了不同的食物产品(麦卢卡蜂蜜、米糠和大豆)进行了筛查实验。不幸的是，补充麦卢卡蜂蜜和大豆并没有改善结肠炎。因此，我们旨在阐明水稻米糠(Rb)对2.0%葡聚糖硫酸钠(DSS)结肠炎C57BL/6L小鼠模型的干预作用的分子机制。饲喂BR的小鼠体重减轻、疾病活动指数、结肠长度和结肠组织病理学均得到改善。时程微生物组和代谢组学结果表明，与RB相关的肠道环境变化可以通过建立肠道内环境平衡来预防结肠炎。我们的方法是开发Rb新的治疗应用的重要工具。

In this year, we conducted a screening experiment using different food products (Manuka Honey, Rice Bran and Soy Beans) in the animal models that we have created in last year.Unfortunately, Manuka Homey and Soy Beans supplementation did not improve colitis. As such, we aimed to elucidate the molecular mechanisms of Oryza sativa, rice bran(RB) dietrary intervention on 2.0% dextran sulfate sodium (DSS)-included colitis C57BL/6L mice mode. Body weight loss, disease activity index, colon length and colon histopathology were improved in BR-fed mice. Time-course microbiome and metabolome results suggest that RB-related alterations of gut environment can prevent colitis via establishing gut homeostasis. Our approach is an important tool in developing new therapeutic applications of RB.