Dystrophin intron retention analysis to identify new targets for Antisense Oligonucleotide mediated RNA modulation in Rhabdomyosarcoma

抗肌营养不良蛋白内含子保留分析以确定横纹肌肉瘤中反义寡核苷酸介导的 RNA 调节的新靶点

• 批准号: 16K07216
• 负责人: NIBA TABE EMMA EKO
• 金额: $ 3.16万
• 依托单位: Kobe University (2017-2018)Kobe Gakuin University (2016)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07216/
• 关键词: Splicing、; Intron retention,; Dystrophin,; Antisense oligo,; Rhabdomyosarcoma; splicing,; intron retention,; dystrophin,; antisense chemistry,; rhabdomyosarcoma,; tumor,; tumor suppressor gene,; Dystrophin; Intron retention; Splicing; AO th

项目成果

Gender effects on the clinical phenotype in Japanese patients with spinal muscular atrophy.

性别对日本脊髓性肌萎缩症患者临床表型的影响。

• 发表时间: 2017
• 期刊: Kobe J Med Sci
• 作者: Ar Rochmah M;Shima A;Harahap NIF;Niba ETE;Morisada N;Yanagisawa S;Saito T;Kaneko K;Saito K;Morioka I;Iijima K;Lai PS;Bouike Y;Nishio H;Shinohara M
• 通讯作者: Shinohara M

New, improved version of the mCOP-PCR screening system for detection of spinal muscular atrophy Gene (SMN1) deletion.

新的改进版 mCOP-PCR 筛查系统，用于检测脊髓性肌萎缩症基因 (SMN1) 缺失。

• 发表时间: 2017
• 期刊: Kobe J Med Sci
• 作者: Shinohara M;Ar Rochmah M;Nakanishi K;Harahap NIF;Niba ETE;Saito T;Saito K;Takeuchi A;Bouike Y;Nishio H
• 通讯作者: Nishio H

SMA Diagnosis: Detection of SMN1 Deletion with Real-Time mCOP-PCR System Using Fresh Blood DNA.

SMA 诊断：使用新鲜血液 DNA 通过实时 mCOP-PCR 系统检测 SMN1 缺失。

• 发表时间: 2017
• 期刊: The Kobe journal of medical sciences
• 作者: Emma Tabe Eko Niba;Mawaddah Ar Rochmah;N. Harahap;H. Awano;I. Morioka;K. Iijima;Toshio Saito;Kayoko Saito;A. Takeuchi;P. Lai;Y. Bouike;H. Nishio;M. Shinohara
• 通讯作者: M. Shinohara

DMD transcription profiling in spontaneously developed tumor from three mdx mice revealed extensive intron retentions and Dp71 isoform expression

三只 mdx 小鼠自发肿瘤的 DMD 转录谱揭示了广泛的内含子保留和 Dp71 亚型表达

• 发表时间: 2018
• 作者: Emma E.T. Niba;Noriyuki Nishimura;Satoru Takafuji;Khin Kyae Mon Thwin;Nobuyuki Yamamoto;Hiroyuki Awano;Shoji Fukushima;Kyoko Itoh;Hisahide Nishio;Masafumi Matsuo
• 通讯作者: Masafumi Matsuo

Spontaneous development of spindle cell sarcoma in mdx mice

mdx小鼠梭形细胞肉瘤的自发发育

• 发表时间: 2018
• 作者: : Satoru Takafuji;Emma Niba;Khin Kyae Mon Thwin;Nobuyuki Yamamoto;Hiroyuki Awano;Suguru Uemura;Takeshi Mori;Shoji Fukushima;Kyoko Itoh;Hisahide Nishio;Masafumi Matsuo;Kazumoto Iijima;Noriyuki Nishimura
• 通讯作者: Noriyuki Nishimura