Elucidation of the mechanism of action of novel antiepileptic drugs using functionalized magnetic nanoparticles and exploration of their neuroprotective effects

利用功能化磁性纳米粒子阐明新型抗癫痫药物的作用机制并探索其神经保护作用

• 批准号: 16K10000
• 负责人: Yamanaka Gaku
• 金额: $ 2.91万
• 依托单位: Tokyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10000/
• 关键词: サイトカイン; 急性脳症; てんかん; 新規抗てんかん薬; アポトーシス; 炎症; 機能性ナノ磁気微粒子; モデルマウス; 脳保護; フローサイトメトリー; 脳症

项目成果

Thermolabile polymorphism of carnitine palmitoyltransferase 2: A genetic risk factor of overall acute encephalopathy

肉毒碱棕榈酰转移酶 2 的耐热多态性：整体急性脑病的遗传危险因素

• DOI: 10.1016/j.braindev.2019.07.008
• 发表时间: 2019
• 期刊: Brain and Development
• 影响因子: 1.7
• 作者: Shibata Akiko;Kasai Mariko;Hoshino Ai;Miyagawa Taku;Matsumoto Hiroshi;Yamanaka Gaku;Kikuchi Kenjiro;Kuki Ichiro;Kumakura Akira;Hara Shinya;Shiihara Takashi;Yamazaki Sawako;Ohta Masayasu;Yamagata Takanori;Takanashi Jun-ichi;Kubota Masaya;Oka Akira;Mizuguch
• 通讯作者: Mizuguch

Relationship between Sedative Antihistamines and the Duration of Febrile Seizures

• DOI: 10.1055/s-0040-1701226
• 发表时间: 2020-04-01
• 期刊: NEUROPEDIATRICS
• 影响因子: 1.4
• 作者: Daida, Atsuro;Yamanaka, Gaku;Kawashima, Hisashi
• 通讯作者: Kawashima, Hisashi

Serial Analysis of Multiple Serum Cytokine Responses to Adrenocorticotropic Hormone Therapy in Patients With West Syndrome

West 综合征患者对促肾上腺皮质激素治疗的多种血清细胞因子反应的系列分析

• DOI: 10.1177/0883073818770764
• 发表时间: 2018
• 期刊: Journal of Child Neurology
• 影响因子: 1.9
• 作者: Yamanaka Gaku;Morishita Natsumi;Morichi Shinichiro;Takeshita Mika;Tomomi Urabe;Ishida Yu;Tomoko Takamatsu;Oana Shingo;Watanabe Yusuke;Go Soken;Kashiwagi Yasuyo;Kawashima Hisashi
• 通讯作者: Kawashima Hisashi

Cytokine Profiling in a Familial Case of Autoimmune Lymphoproliferative Syndrome with Co-mutations of FAS and MEFV

伴有 FAS 和 MEFV 共突变的自身免疫性淋巴增殖综合征家族性病例的细胞因子分析

• 发表时间: 2017
• 期刊: Pediatric Allergy, Immunology, and Pulmonology
• 作者: Hatsushika T;Ushio M;Suzuki S;Suzuki S;Yamanaka G;Kashiwagi Y;Yanase N;Kawashima H
• 通讯作者: Kawashima H

Cytokine and chemokine responses in clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) by type

临床轻度脑炎/脑病伴有可逆性压部病变 (MERS) 的细胞因子和趋化因子反应（按类型）

• 发表时间: 2018
• 作者: Morichi S;Kimura M;Takamatsu T;Morishita N;Takeshita M;Ishida Y;Oana S;Yamanaka G;Kashiwagi Y;Kawashima H
• 通讯作者: Kawashima H