Prediction of the genetic and epigenetic risks associated with lifestyle-related diseases in the population-based confirmatory factor analysis

基于人群的验证性因素分析预测与生活方式相关疾病相关的遗传和表观遗传风险

• 批准号: 16H05250
• 负责人: Yokota Mitsuhiro
• 金额: $ 10.57万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05250/
• 关键词: 生活習慣病; 心筋梗塞; 糖尿病; 高血圧症; 肥満; 喫煙; 遺伝子多型解析; ＧＷＡＳ; GWAS; EWAS; ゲノム疫学; エピゲノム; 罹患同胞対連鎖解析; ゲノムワイドDNAメチル化; ゲノムワイドDNAメチル化解析

项目成果

Analysis of the association between DNA methylation sites and cardiovascular disease-related single nucleotide polymorphisms in the Japanese population

日本人群DNA甲基化位点与心血管疾病相关单核苷酸多态性的关联分析

• 发表时间: 2016
• 作者: Masahiro Nakatochi;Sahoko Ichihara;Ken Yamamoto;Tatsuaki Matsubara;Mitsuhiro Yokota
• 通讯作者: Mitsuhiro Yokota

Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

• DOI: 10.1038/s41467-018-07345-0
• 发表时间: 2018-11-28
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Takeuchi F;Akiyama M;Matoba N;Katsuya T;Nakatochi M;Tabara Y;Narita A;Saw WY;Moon S;Spracklen CN;Chai JF;Kim YJ;Zhang L;Wang C;Li H;Li H;Wu JY;Dorajoo R;Nierenberg JL;Wang YX;He J;Bennett DA;Takahashi A;Momozawa Y;Hirata M;Matsuda K;Rakugi H;Nakashima E;Isono M;Shirota M;Hozawa A;Ichihara S;Matsubara T;Yamamoto K;Kohara K;Igase M;Han S;Gordon-Larsen P;Huang W;Lee NR;Adair LS;Hwang MY;Lee J;Chee ML;Sabanayagam C;Zhao W;Liu J;Reilly DF;Sun L;Huo S;Edwards TL;Long J;Chang LC;Chen CH;Yuan JM;Koh WP;Friedlander Y;Kelly TN;Bin Wei W;Xu L;Cai H;Xiang YB;Lin K;Clarke R;Walters RG;Millwood IY;Li L;Chambers JC;Kooner JS;Elliott P;van der Harst P;International Genomics of Blood Pressure (iGEN-BP) Consortium;Chen Z;Sasaki M;Shu XO;Jonas JB;He J;Heng CK;Chen YT;Zheng W;Lin X;Teo YY;Tai ES;Cheng CY;Wong TY;Sim X;Mohlke KL;Yamamoto M;Kim BJ;Miki T;Nabika T;Yokota M;Kamatani Y;Kubo M;Kato N
• 通讯作者: Kato N

Characterising private and shared signatures of positive selection in 37 Asian populations

描述 37 个亚洲人群的私人和共同的积极选择特征。

• DOI: 10.1038/ejhg.2016.181
• 发表时间: 2017-04-01
• 期刊: EUROPEAN JOURNAL OF HUMAN GENETICS
• 影响因子: 5.2
• 作者: Liu, Xuanyao;Lu, Dongsheng;Teo, Yik-Ying
• 通讯作者: Teo, Yik-Ying

Epigenetic ageとChronological ageの差分値は非致死性心筋梗塞と関連しない

表观遗传年龄和实际年龄之间的差异与非致命性心肌梗死无关

• 发表时间: 2016
• 作者: 中杤昌弘;市原佐保子;山本健;松原達昭;横田充弘
• 通讯作者: 横田充弘

Association analysis among myocardial infarction, cardiovascular disease-related single nucleotide polymorphisms, and DNA methylation sites utilizing the cluster analysis

利用聚类分析对心肌梗死、心血管疾病相关单核苷酸多态性和DNA甲基化位点进行关联分析

• 发表时间: 2017
• 作者: Masahiro Nakatochi;Sahoko Ichihara;Ken Yamamoto;Tatsuaki Matsubara;Mitsuhiro Yokota
• 通讯作者: Mitsuhiro Yokota