Elucidation of Involvement of LOX-1 in inflammatory bone destruction and the molecular mechanism for the LOX-1 actions, and an approach to develop the new drug for bone diseases.
Elucidation of Involvement of LOX-1 in inflammatory bone destruction and the molecular mechanism for the LOX-1 actions, and an approach to develop the new drug for bone diseases.
批准号:
16H05505
负责人:
HAKEDA Yoshiyuki
金额:
$11.07万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2016
资助国家:
日本
项目状态:
已结题
起止时间:
2016-04-01 至 2020-03-31
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Low-density lipoproteinの細胞内への取り込みに依存したホスファチジルエタノールアミンの細胞膜外葉への局在変換は破骨細胞の融合過程に関与する
磷脂酰乙醇胺定位于细胞膜的外叶,这取决于细胞对低密度脂蛋白的摄取,参与破骨细胞的融合过程。
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[羽毛田慈之、Victor Jose Flores Kitano, 大山洋子、林田千代美、佐藤卓也、嶋田淳]
通讯作者:
大山洋子、林田千代美、佐藤卓也、嶋田淳
スダチ果皮特有ポリメトキシフラボノイドsudachitinは破骨細胞形成およびLPS誘導炎症性骨破壊を抑制する
Sudachitin 是 Sudachi 果皮特有的一种多甲氧基黄酮类化合物,可抑制破骨细胞形成和 LPS 诱导的炎症性骨质破坏
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[伊東順太, 大山洋子, 林田千代美, 佐藤卓也, 羽毛田慈之]
通讯作者:
羽毛田慈之
Sudachitin, a polymethoxyflavone derived from Citrus sudachi, suppresses lipopolysaccharide-induced inflammatory bone resorption because of inhibiting osteoclast formation in mice
Sudachitin 是一种从柑橘中提取的多甲氧基黄酮,通过抑制小鼠破骨细胞的形成来抑制脂多糖诱导的炎症性骨吸收
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Ohyama Y., Ito J.,Hakeda Y., Shimada J.]
通讯作者:
Shimada J.
DOI:
10.1242/jcs.243840
发表时间:
2020-05-01
期刊:
JOURNAL OF CELL SCIENCE
影响因子:
4
作者:
[Kitano, Victor J. F., Ohyama, Yoko, Hakeda, Yoshiyuki]
通讯作者:
Hakeda, Yoshiyuki
Trial study for the establishment of the new therapeutical method for periodontal disease that targets oxidation LDL receptor LOX-1.
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批准号:26670895
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2014
-
负责人:HAKEDA Yoshiyuki
-
依托单位:
The elucidation of the role of lipid in bone resorption of inflammatory bone diseases; in particular, the exploration of the role of LOX-1 as an oxidized LDL receptor
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批准号:25293376
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.32万
-
财政年份:2013
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负责人:HAKEDA Yoshiyuki
-
依托单位:
DEPENDENCY OF OSTEOCLAST DIFFERENTIATION ON EXOGENOUS CHOLESTEROL AND ROLE OF CAVEOLIN-1 IN OSTEOCLASTOGENESIS
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批准号:21592341
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2009
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负责人:HAKEDA Yoshiyuki
-
依托单位:
Elucidation on roles of caveolae/lipid raft on osteoclast differentiation and bone resorption and on intracellular trafficking of caveolin-1
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批准号:19592130
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:HAKEDA Yoshiyuki
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依托单位:
Investigation of action of shear stress, which is produced by Mechanical loading applied to the skeleton, on osteodast formation and bone-resorbing activity
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批准号:17591922
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:HAKEDA Yoshiyuki
-
依托单位:
Elucidation of role of beta ig-3 derived from osteoclasts in bone resorption and formation
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批准号:15591946
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
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财政年份:2003
-
负责人:HAKEDA Yoshiyuki
-
依托单位:
Elucidation of regulatory mechanism of osteoclast differentiation and function by extracellular calcium and phosphorus.
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批准号:12671780
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:2000
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负责人:HAKEDA Yoshiyuki
-
依托单位:
Study on direct action of estrogen on mature osteoclasts
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批准号:08672087
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1996
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负责人:HAKEDA Yoshiyuki
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依托单位:
Analysis of osteoclast-specificmembrane-bound proteins that are expressed during osteoclast differentiation
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批准号:06671825
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1994
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负责人:HAKEDA Yoshiyuki
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依托单位:
海外基金