The elucidation of the role of lipid in bone resorption of inflammatory bone diseases; in particular, the exploration of the role of LOX-1 as an oxidized LDL receptor
The elucidation of the role of lipid in bone resorption of inflammatory bone diseases; in particular, the exploration of the role of LOX-1 as an oxidized LDL receptor
批准号:
25293376
负责人:
HAKEDA Yoshiyuki
金额:
$11.32万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2013
资助国家:
日本
项目状态:
已结题
起止时间:
2013-04-01 至 2016-03-31
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レクチン様酸化LDL受容体-1 (LOX-1)欠損は定常状態における破骨細胞形成を促進するが、LPS誘導炎症性骨破壊に抵抗性を示す
凝集素样氧化 LDL 受体 1 (LOX-1) 缺乏促进稳态破骨细胞生成,但对 LPS 诱导的炎症性骨破坏具有抵抗力
DOI:
--
发表时间:
2015
期刊:
影响因子:
--
作者:
[伊東 順太, 林田 千代美, 大山 洋子, 佐藤 卓也, 羽毛田 慈之]
通讯作者:
羽毛田 慈之
レクチン様酸化LDL受容体-1(LOX-1)の破骨細胞形成と炎症性骨破壊に対する役割の解明
阐明凝集素样氧化 LDL 受体-1 (LOX-1) 对破骨细胞形成和炎性骨质破坏的作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[伊東順太, 中谷地舞, 林田千代美, 岡安麻里, 大山洋子, 佐藤卓也, 羽毛田慈之]
通讯作者:
羽毛田慈之
Lectin-like oxidized low-density of lipoprotein receptor-1 is involved in RANKL-production elevated by lipopolysaccharide-injection on mouse calvaria and thereby contributes to inflammatory bone destruction
凝集素样氧化低密度脂蛋白受体-1参与通过在小鼠颅骨上注射脂多糖而增加的RANKL产生,从而导致炎症性骨破坏
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Nakayachi M, Ito J, Okayasu M, Hayashida C, Sato T, Suda N, Sawamura T, Hakeda Y.]
通讯作者:
Hakeda Y.
レクチン様酸化LDL受容体-1(LOX-1)の破骨細胞形成および炎症性骨吸収に果たす役割の解明
阐明凝集素样氧化 LDL 受体-1 (LOX-1) 在破骨细胞形成和炎症性骨吸收中的作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[中谷地舞, 伊東順太, 岡安麻里, 須田直人, 羽毛田慈之]
通讯作者:
羽毛田慈之
伊東順太、林田千代美、大山洋子、佐藤卓也、羽毛田慈之
伊藤淳太、林田千代美、小山洋子、佐藤拓也、羽田佳之
DOI:
--
发表时间:
2015
期刊:
影响因子:
--
作者:
[レクチン様酸化LDL受容体-1 (LOX-1)欠損は定常状態における破骨細胞形成を促進するが, LPS誘導炎症性骨破壊に抵抗性を示す]
通讯作者:
LPS誘導炎症性骨破壊に抵抗性を示す
共 8 条
Elucidation of Involvement of LOX-1 in inflammatory bone destruction and the molecular mechanism for the LOX-1 actions, and an approach to develop the new drug for bone diseases.
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批准号:16H05505
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.07万
-
财政年份:2016
-
负责人:HAKEDA Yoshiyuki
-
依托单位:
Trial study for the establishment of the new therapeutical method for periodontal disease that targets oxidation LDL receptor LOX-1.
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批准号:26670895
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2014
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负责人:HAKEDA Yoshiyuki
-
依托单位:
DEPENDENCY OF OSTEOCLAST DIFFERENTIATION ON EXOGENOUS CHOLESTEROL AND ROLE OF CAVEOLIN-1 IN OSTEOCLASTOGENESIS
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批准号:21592341
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2009
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负责人:HAKEDA Yoshiyuki
-
依托单位:
Elucidation on roles of caveolae/lipid raft on osteoclast differentiation and bone resorption and on intracellular trafficking of caveolin-1
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批准号:19592130
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2007
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负责人:HAKEDA Yoshiyuki
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依托单位:
Investigation of action of shear stress, which is produced by Mechanical loading applied to the skeleton, on osteodast formation and bone-resorbing activity
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批准号:17591922
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:HAKEDA Yoshiyuki
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依托单位:
Elucidation of role of beta ig-3 derived from osteoclasts in bone resorption and formation
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批准号:15591946
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:HAKEDA Yoshiyuki
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依托单位:
Elucidation of regulatory mechanism of osteoclast differentiation and function by extracellular calcium and phosphorus.
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批准号:12671780
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:2000
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负责人:HAKEDA Yoshiyuki
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依托单位:
Study on direct action of estrogen on mature osteoclasts
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批准号:08672087
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1996
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负责人:HAKEDA Yoshiyuki
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依托单位:
Analysis of osteoclast-specificmembrane-bound proteins that are expressed during osteoclast differentiation
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批准号:06671825
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1994
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负责人:HAKEDA Yoshiyuki
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依托单位:
海外基金