Gamma oscillations in the human EEG as signature of use-dependent formation and activation of cortical networks related to memory processes

人类脑电图的伽马振荡是与记忆过程相关的皮质网络的使用依赖性形成和激活的特征

• 批准号: 5450335
• 负责人: Professor Dr. Thomas Gruber
• 金额: --
• 依托单位: Fachgebiet Allgemeine Psychologie I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2005
• 资助国家: 德国
• 起止时间: 2004-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5450335?language=en
• 关键词: Gamma; oscillations; human; EEG; signature

One of the more fundamental puzzles in neuroscience is how the brain integrates its distributed cortical activities. A powerful associative mechanism was proposed by Hebb (1949), which stated that specific functions of different brain areas are integrated by dynamical binding of ¿cell assemblies¿. This idea has intrigued investigators since its formulation, but the technology to demonstrate its existence had been lacking until the past decade. Recently, human EEG studies on basic perceptual processing have shown that oscillatory brain activity in the garnma band (bigger as 20 Hz) correlates with the activation of such networks. Furthermore, in a series of preliminary studies, we demonstrated that gamma band responses (GBRS) are not only related to basic perception, but reflect different forms of memory. Based on these findings, the present project will examine the hypothesis that GBRs mirror the use-dependent fonnation/activation of large-scale networks related to mnemonic ftmctioning. The dynamics of these networks will be investigated in different memory systems (implicit and explicit memory) and due to multiple retrieval processes (e.g. familiarity versus recollection). In addition, we will impel the development of analysis techniques to uncover cortical (and possibly subcortical) sources of oscillatory brain activity. The outcome of the proposed project will significantly complement contemporary theoretical models of human memory.

神经科学中一个更基本的难题是，大脑如何整合其分布的皮质活动。Hebb(1949)提出了一种强大的联想机制，认为不同脑区的特定功能是通过细胞集合的动态结合来整合的。这一想法自提出以来就一直吸引着调查人员，但直到过去十年，还缺乏证明其存在的技术。最近，人类脑电关于基本知觉处理的研究表明，大脑在Garnma频段(大于20赫兹)的振荡活动与这种网络的激活有关。此外，在一系列的初步研究中，我们证明了伽玛波段反应(GBR)不仅与基本知觉有关，而且反映了不同形式的记忆。基于这些发现，本项目将检验这一假设，即GBR反映了与记忆迁移相关的大规模网络的使用依赖的形成/激活。这些网络的动态将在不同的记忆系统(内隐和外显记忆)中进行研究，并由于多个提取过程(例如熟悉和回忆)而被研究。此外，我们将推动分析技术的发展，以揭示大脑振荡活动的皮质(可能是皮质下)来源。该项目的成果将极大地补充当代人类记忆的理论模型。