Spatiotemporal dynamics within memory traces studied by induced gamma-band oscillations in the human EEG and coupling measures in source space

记忆研究中的一个更基本的问题是，大脑如何整合分布式存储和执行皮质区域，这些区域是激活特定的“记忆痕迹”所必需的。假设这种积分是通过伽马频段(&gt；25 hz)的同步振荡来实现的。具体地说，诱发的伽马反应(iGBR；~150-400ms)可能代表概念记忆的激活，而诱发的伽马反应(eGBRs；~90ms)可能反映知觉记忆。本项目的第一个目标是加深对内隐和外显记忆过程中这种记忆痕迹改变机制的认识。为此，我们将依赖于重复的刺激方案。第二个中心目标是通过高级分析程序来检查特定记忆痕迹内的时空动力学：(A)伽马频带源重建和(B)源空间中的功能和有效的耦合措施。记忆的互补关联(ERPs，低频振荡)将被研究它们与伽马振荡的关系。

One of the more fundamental questions in memory research is how the brain integrates the distributed storage- and executive cortical areas necessary for the activation of a specific ‘memory trace’. It is hypothesized that this integration is achieved by synchronized oscillations in the gamma-band frequency range (>25Hz). In particular, induced gamma-band responses (iGBRs; ~150-400ms) might signify the activation of conceptual engrams, whereas evoked gamma-band responses (eGBRs; ~90ms) might mirror perceptual memory.The first goal of present project is to deepen the knowledge regarding the mechanism by which such memory traces are altered during implicit and explicit memory. To that end, we will rely on stimulus repetition designs. A second central aim is the examination of the spatiotemporal dynamics within specific memory traces by means of advanced analysis procedures: (a) Gamma-band source reconstructions and (b) functional and effective coupling measures in source space.Complementary correlates of memory (ERPs, lower-frequency oscillations) will be studied in their relation to gamma oscillations.