Spatiotemporal dynamics within memory traces studied by induced gamma-band oscillations in the human EEG and coupling measures in source space

通过人类脑电图感应伽玛波段振荡和源空间耦合测量研究记忆痕迹内的时空动力学

• 批准号: 72251038
• 负责人: Professor Dr. Thomas Gruber
• 金额: --
• 依托单位: Fachgebiet Allgemeine Psychologie I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/72251038?language=en
• 关键词: Spatiotemporal; dynamics; within; memory; traces

One of the more fundamental questions in memory research is how the brain integrates the distributed storage- and executive cortical areas necessary for the activation of a specific ‘memory trace’. It is hypothesized that this integration is achieved by synchronized oscillations in the gamma-band frequency range (>25Hz). In particular, induced gamma-band responses (iGBRs; ~150-400ms) might signify the activation of conceptual engrams, whereas evoked gamma-band responses (eGBRs; ~90ms) might mirror perceptual memory.The first goal of present project is to deepen the knowledge regarding the mechanism by which such memory traces are altered during implicit and explicit memory. To that end, we will rely on stimulus repetition designs. A second central aim is the examination of the spatiotemporal dynamics within specific memory traces by means of advanced analysis procedures: (a) Gamma-band source reconstructions and (b) functional and effective coupling measures in source space.Complementary correlates of memory (ERPs, lower-frequency oscillations) will be studied in their relation to gamma oscillations.

记忆研究中更基本的问题之一是大脑如何整合激活特定“记忆痕迹”所需的分布式存储和执行皮质区域。假设这种积分是通过伽马带频率范围（>25Hz）中的同步振荡来实现的。特别是，诱发的伽玛带反应（iGBR；~150-400ms）可能意味着概念印迹的激活，而诱发的伽玛带反应（eGBR；~90ms）可能反映知觉记忆。本项目的第一个目标是加深对在内隐和外显记忆期间改变此类记忆痕迹的机制的了解。为此，我们将依靠刺激重复设计。第二个中心目标是通过先进的分析程序检查特定记忆痕迹内的时空动态：（a）伽马带源重建和（b）源空间中的功能和有效耦合措施。将研究记忆的互补相关性（ERP，低频振荡）与伽马振荡的关系。