权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Steadily self-reproducing vesicles oriented to an evolvable chemical system

面向可进化化学系统的稳定自我复制的囊泡

基本信息

批准号：
18J22004
负责人：
杉山博紀
金额：
$ 1.41万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2018
资助国家：
日本
起止时间：
2018-04-25 至 2021-03-31
项目状态：
已结题

项目摘要

ジャイアントベシクル（GV）の自己再生産動態を定常化するうえで，内水相への連続的な基質送達が課題であった．前年度までに開発してきた，マイクロ流体デバイスを基軸とする自動計測システムを用いて発見された，脂質二分子膜を介した濃度勾配に逆らって分子が濃縮される新奇の輸送動態はこの課題の根本的解決につながりうる．この輸送動態がいかなる機構で生じるのかを明らかにすることで，本現象の適用範囲や応用可能性を見定めることができる．本年度はまず，分子濃縮の機構解明を目的として研究を進めた．GVを定常的な流れ環境下にさらすことで生じる膜揺動が本質的な役割を果たすことが分かった．この成果は2020年7月，同年9月，同年11月にそれぞれ開催されたMolecular origin of life，第58回日本生物物理学会年会，細胞を創る研究会13.0にて発表した．これまでGVの流れ環境下での様態を報告した例はあるものの，具体的なGVの機能との連関を議論した報告は限定的であり，これらの成果報告は大きな注目を集め，特に日本生物物理学会年会では，学生発表賞を受賞した．さらに現在，国際誌に原著論文として投稿中である．また，本成果に関連する研究内容について，報告者を連名発表者として，国際学会で招待講演を受けた．また，開発した自動計測システムの適用範囲を広げる試みとして，前年度から継続してデバイスの表面修飾法の検討を進めていた．結果として，内包効率に優れる油中水滴エマルション遠心沈降法で作成されたリポソームをデバイス内部で計測可能となった．本成果は，2020年7月にACS Omegaにて採択・公開された．これらの一連の研究成果は国内の関連分野の研究者の注目を集め，複数の共同研究へと発展している．

You can regenerate the dynamic system by yourself, normalize the system, and send the basic information of the internal water phase connection to the problem. In the previous year, the system started to operate in the previous year, and the basic information of the automatic control system was used. The lipid bilayer membrane is equipped with an inverse molecular model, which is a novel method for the fundamental solution to the problem of the dynamics problem. You can send it to the health care system of the health care system. This is like using the range to determine the feasibility of the system. This is the year of the year. Molecular engineering institutions explain that the purpose of this study is to improve the performance of the study. GV has been established in the environment of environmental pollution. The results of the study were reviewed in July 2020, September of the same year, November of the same year, and the annual meeting of the Biophysics Society of Japan was launched in July 2020, September of the same year and November of the same year. The annual report of the National Biophysics Society of Japan has attracted a lot of attention, the annual meeting of the Japanese Biophysics Society, the annual meeting of the Japanese Biophysics Society, the annual meeting of the Japanese Biophysics Society, the annual meeting of the Japanese Biophysics Society, the annual meeting of the Japanese Biophysics Society, the annual meeting of the Japanese Biophysics Society, the annual meeting of the Japanese Biophysics Society, and the annual meeting of the Japanese Biophysical Society. In the original articles of the International Academy of Sciences, the contents of the research were reviewed, the informants were linked to the list, and the International Society for International Studies was invited to entertain the performers. The program is open to the use of the scope of the automatic program, the scope of the program, the scope of the software, and the surface repair method of the previous year, and the results were satisfactory. In this paper, the results show that the results of ACS Omega research in July 2020 are related to the results of the study in July 2010. in this paper, the results show that the research results in July 2020 are related to the results of the study in July 2010. the results show that the research results in July 2020 are linked to the focus of domestic researchers' attention, and the multiplicity of joint research and exhibition.