肝腫瘍におけるvessel co-optionのイメージバイオマーカーの開発

肝脏肿瘤血管选择图像生物标志物的开发

• 批准号: 22K07662
• 负责人: 小坂 一斗
• 金额: $ 2.5万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K07662/
• 关键词: 肝腫瘍; 肝内胆管癌; 血管新生; イメージバイオマーカー

iMCC 7例を対象（切除例）として病理所見にて腫瘍内の脈管、血洞を評価し、動注CT所見との対比を行ったところ、全例周辺肝に対し置換性発育を示し、内部に門脈域（PT）を認めた。腫瘍内動脈（HA）は、門脈（PV）・胆管(B)に伴走するHA（A-type1）、Bのみが伴走するHA（A-type2）、小線維帯内でPV・BのないHA（A-type3）、線維帯を有しないHA（A-type4）に分類され、薄壁血管も観察された（probable HV）。CTAPでは全例血流欠損、CTHA1st-phaseでは3例が腫瘤全体濃染と周辺に楔状早期濃染、2nd-phaseで全体に濃染は持続し周辺楔状濃染も拡大を示し、腫瘍辺縁からHVへの還流を観察され、またinterfaceではPT・HVが拡張・増加、腫瘍内HAはA-type2, 3が主で、probable HVは散在、CD34陽性血洞が観察。残り４例はCTHA 1st-phaseで腫瘍辺縁濃染と楔状早期濃染を認め、変性を伴っていた。非変性部やinterface、周辺肝の脈管系は先の3例と同様であったことからiMCCは、腫瘍辺縁はAP-shuntで、腫瘍内部はPT内HA遺残で栄養され、腫瘍血洞を潅流後interfaceと周辺肝HVを経て還流すると考えられた。進行するとinterfaceと周辺肝のAP shuntからの腫瘍血洞への血流が主体となると考えられた。

7 cases of iMCC were detected by pathology, blood vessels and blood holes in tumor were evaluated, and all cases were detected by peripheral liver, replacement development and internal portal domain (PT). HA (A-type 1), HA (A-type 2), HA (A-type 3), HA (A-type 4), HA (A-type 3), HA (A-type 4), HA (A-type 1), HA (A-type 1), HA (A-type 2), HA (A-type 3), HA (A-type 4), HA (A-type 1), HA (A-type 2), HA (A-type 3), HA (A-type 3), HA (A-type 4), HA (A-type 3), HA (A-type 4), HA (A-type 3), HA (A-type 3), HA (A-type 4), HA (A-type 4), HA (A-type 1), HA (A-type 2), HA (A-type 3), HA (A-type 3), HA (A-type 4), HA (A-type 3), HA (A-type 3), HA (A-type 4), HA (A-type 3), HA ( CTAP showed poor blood flow in all cases, CTHA 1st-phase in 3 cases, whole tumor in early wedge-like staining in 2nd-phase, whole tumor in early wedge-like staining in 2nd-phase, whole tumor in early wedge-like staining in early wedge-like 4 cases of CTHA 1st-phase swelling, wedge-shaped early staining, and sex The blood vessel system of the liver in the non-cancerous part of the liver is divided into three parts: the first part of the liver is divided into three parts: the first part of the liver is divided into three parts: the second part of the liver is divided into three parts: the first part of the liver is divided into three parts: the first part of the liver is divided into three parts: the first part of the liver is divided into three parts: the second part of the liver is divided into three parts: the first part of the liver is divided into three parts: the second part of the liver is divided into three parts: the third part of the liver is divided into four parts: the third part of the liver is divided into three parts: the third part of the liver is divided into four parts: the third part of the liver is divided into three parts: the fourth part of the liver is divided into four parts: the third part of the liver is divided into three parts: the fourth part of the liver is divided into four parts: the third part of the liver is divided into four parts: the third part of the liver is divided into three parts: the liver is divided into four parts: the third part of The blood flow in the liver is mainly due to the swelling and bleeding.