Applied Venom Proteomics / Venomics

拟议的项目结合了德国和巴西研究小组的科学潜力，研究来自欧洲和巴西生物多样性的选定昆虫、蛇和蜘蛛毒液的新蛋白质和其他生物分子的结构、功能、生物技术和药理学方面。这项合作（见意向书）将利用专业知识和分析技术的复杂结合，以及动物和昆虫毒液的交换。我们计划首次以比较的方式详细确定选定毒液的蛋白质组学组成。我们的初步调查显示，欧洲蛇的毒液中有100多种不同的蛋白质成分，其中50%是未知的化合物。我们将分离和表征影响血液凝固和凝血，利什曼病和肿瘤生长的新型毒液蛋白。对毒液成分的详细了解将有助于生产具有更高中和效果的特异性抗蛇毒血清，并有助于研究重要的生理过程。除了拟议的联合研究外，德国和巴西共同指导的博士生的跨学科培训和教育将得到高度优先考虑。对于博士研究员，将实施交换计划。

The proposed project unifies the scientific potential of German and Brazilian research groups for investigating structural, functional, biotechnological and pharmacological aspects of novel proteins and other biomolecules from selected insect, snake and spider venoms from the biodiversity of Europe and Brazil. The collaboration (see letter of intent) will utilize a sophisticated combination of know how and analytical techniques, as well as exchange of animal and insect venoms.We plan to determine in detail for the firs time and in a comparative way, the proteomic compostiions of selceted venoms. Our preliminary investigations showed more than 100 different protein components in the venom of a European snake, 50% of them being unknown compounds. We will isolate and characterize novel venom proteins affecting blood coagulation and clotting, Leishmaniasis and tumor growth. Detailed knowledge of the venom composition will allow the production of specific antivenoms with increased neutralizing effectivness and the investigation of important physiological processes. Beside the proposed joint research the interdisciplinary training and education of the commonly supervised PhD students from the German and Brazilian groups will be given a high priority. For the PhD fellows an exchange program will be implemented.