Applied Venom Proteomics / Venomics

应用毒液蛋白质组学/毒液组学

• 批准号: 61641854
• 负责人: Professor Dr. Christian Betzel
• 金额: --
• 依托单位: Laboratorium für Strukturbiologie von Infektion und Entzündung
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/61641854?language=en
• 关键词: Applied; Venom; Proteomics; Venomics

The proposed project unifies the scientific potential of German and Brazilian research groups for investigating structural, functional, biotechnological and pharmacological aspects of novel proteins and other biomolecules from selected insect, snake and spider venoms from the biodiversity of Europe and Brazil. The collaboration (see letter of intent) will utilize a sophisticated combination of know how and analytical techniques, as well as exchange of animal and insect venoms.We plan to determine in detail for the firs time and in a comparative way, the proteomic compostiions of selceted venoms. Our preliminary investigations showed more than 100 different protein components in the venom of a European snake, 50% of them being unknown compounds. We will isolate and characterize novel venom proteins affecting blood coagulation and clotting, Leishmaniasis and tumor growth. Detailed knowledge of the venom composition will allow the production of specific antivenoms with increased neutralizing effectivness and the investigation of important physiological processes. Beside the proposed joint research the interdisciplinary training and education of the commonly supervised PhD students from the German and Brazilian groups will be given a high priority. For the PhD fellows an exchange program will be implemented.

拟议的项目将德国和巴西研究小组的科学潜力结合起来，以调查来自欧洲和巴西生物多样性的选定昆虫、蛇和蜘蛛毒液的新蛋白质和其他生物分子的结构、功能、生物技术和药理学方面。合作（见意向书）将利用一个复杂的组合的专有技术和分析技术，以及动物和昆虫毒液的交换。我们计划确定详细的第一次和比较的方式，蛋白质组组成的选择毒液。我们的初步调查显示，欧洲蛇的毒液中有100多种不同的蛋白质成分，其中50%是未知化合物。我们将分离和表征影响血液凝固和凝血，利什曼病和肿瘤生长的新型毒液蛋白。对毒液成分的详细了解将允许生产具有增加的中和效力的特异性抗蛇毒血清和重要生理过程的研究。除了拟议的联合研究，来自德国和巴西团体的共同监督的博士生的跨学科培训和教育将得到高度重视。对于博士研究员，将实施交流计划。