Determination of the absolute and relative configuration of natural compounds with improved NMR methods and new orienting media

使用改进的核磁共振方法和新的取向介质测定天然化合物的绝对和相对构型

• 批准号: 71001531
• 负责人: Professor Dr. Christian Griesinger
• 金额: --
• 依托单位: Abteilung NMR-Basierte Strukturbiologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/71001531?language=en
• 关键词: Determination; absolute; relative; configuration; natural

The main goal is to develop and to adapt pulse sequences for natural products in organic solvents to measure dipolar couplings between spins and chemical shift anisotropies at natural abundance. These sequences will then be used by us and other groups to determine the relative and absolute configuration of natural products.

主要目标是开发和调整天然产物在有机溶剂中的脉冲序列，以测量自然丰度下自旋之间的偶极耦合和化学位移各向异性。然后，我们和其他团队将使用这些序列来确定天然产品的相对和绝对构型。

项目成果

Graphene oxide liquid crystals as a versatile and tunable alignment medium for the measurement of residual dipolar couplings in organic solvents.

• DOI: 10.1021/ja506074a
• 发表时间: 2014-08
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Xinxiang Lei;Zhen Xu;Han Sun;Shunchin C. Wang;C. Griesinger;Li-hua Peng;Chao Gao;R. Tan