Mechanofluorescent Surfaces for Understanding Complex Cell Traction Forces

用于理解复杂细胞牵引力的机械荧光表面

• 批准号: DE220100748
• 负责人: Dr Quinn Besford
• 金额: --
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2022-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100748
• 关键词: Mechanofluorescent; Surfaces; Understanding; Complex; Cell

This project aims to develop pressure-sensing surfaces that directly quantify surface forces, focused towards measuring complex cell traction forces. Understanding cell traction forces is a crucial challenge towards developing new materials for regenerative medicine. The surfaces, consisting of fluorescent polymer brushes, are expected to provide direct information on singular and clustered cell forces, which can reveal new insight into how cells interact together. This may provide currently missing information on how cell-surface interaction forces modulate cell growth, differentiation and tissue formation. This insight is crucial to providing the underpinning science that can position Australia at the forefront of regenerative medicine.

该项目旨在开发直接量化表面力的压力传感表面，重点是测量复杂的细胞牵引力。了解细胞的牵引力是开发再生医学新材料的关键挑战。由荧光聚合物刷组成的表面有望提供关于单个和集群细胞力的直接信息，这可以揭示细胞如何相互作用的新见解。这可能提供目前缺失的关于细胞表面相互作用力如何调节细胞生长、分化和组织形成的信息。这种见解对于提供能够使澳大利亚处于再生医学前沿的基础科学至关重要。