Calcium dependent regulation of K+ channels and their role in potassium homeostasis during stress

K 通道的钙依赖性调节及其在应激期间钾稳态中的作用

• 批准号: 71800300
• 负责人: Professor Dr. Dirk Becker
• 金额: --
• 依托单位: Lehrstuhl für Botanik I: Molekulare Pflanzenphysiologie und Biophysik
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/71800300?language=en
• 关键词: Calcium; dependent; regulation; K+; channels

Potassium essentiality in plants is related to its key role as a major inorganic osmoticum and its impact on growth, development and crop yield. On the cellular level K+ transport is accomplished by ion channels and transporters and their regulation by Ca2+ dependent signaling processes is with the focus of our project. The Arabidopsis K+ efflux channel GORK represents a paradigm for voltage dependent, K+ sensing ion channels. We will study the effect of stress induced phosphorylation by Ca2+ dependent kinases on its activity status to reveal its role in K+ homeostasis and sensing. Based on established cooperations with the FOR964 we aim on quantitatively describe and simulate K+-stress induced Ca2+ patterns in selected cell types by means of optogenetic tools thereby gaining new insight into the regulation of plant potassium balance.

钾在植物中的必需性与其作为主要无机营养物质的关键作用及其对作物生长发育和产量的影响有关。在细胞水平上，K+的转运是通过离子通道和转运蛋白来完成的，它们通过依赖于Ca ~（2+）的信号过程来调节是我们项目的重点。拟南芥K+外排通道是一种电压依赖的K+敏感离子通道。我们将研究应激诱导的钙依赖性激酶磷酸化对其活性状态的影响，以揭示其在K+稳态和传感中的作用。基于与FOR 964建立的合作，我们的目标是通过光遗传学工具定量描述和模拟K+胁迫诱导的选定细胞类型中的Ca 2+模式，从而获得对植物钾平衡调节的新见解。