Defining how gut bacteria regulate metabolism: a role for gut serotonin

定义肠道细菌如何调节新陈代谢：肠道血清素的作用

• 批准号: DE220100403
• 负责人: Dr Alyce Martin
• 金额: $ 33.71万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2026-01-24
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100403
• 关键词: Defining; how; gut; bacteria; regulate

This project aims to understand how serotonin-producing cells in the gut interact with gut bacteria (the microbiome), using a combination of cells in culture and live germ-free and genetically modified mice. This project expects to generate new knowledge regarding cellular interactions that underlie important physiological pathways, such as the control of blood glucose and fat storage. The intended outcomes of this project are to identify how gut bacteria communicate with serotonin-producing cells to regulate metabolism, and whether diet acts via a gut microbiome-serotonin axis to impact physiology. The expected benefit of this project will be to provide a new understanding of highly complex physiological systems that regulate our health.

该项目旨在了解肠道中产生5-羟色胺的细胞如何与肠道细菌(微生物群)相互作用，使用培养细胞和活的无菌和转基因小鼠的组合。该项目希望产生关于细胞相互作用的新知识，这些相互作用是重要生理途径的基础，例如血糖和脂肪储存的控制。该项目的预期结果是确定肠道细菌如何与产生5-羟色胺的细胞沟通以调节新陈代谢，以及饮食是否通过肠道微生物组-5-羟色素轴影响生理。这个项目的预期好处将是提供对高度复杂的生理系统的新理解，这些系统调节我们的健康。