Intergenerational social mobility and brain cognitive degeneration.

去年成功申请密歇根州立大学访问学者（2022年9月至2023年2月）；在那里我学习了纵向高维模型分析，以及研究生活方式与认知轨迹相互作用的多个平台的公认资源（正在进行的项目）。除了这个项目，我还与瑞典于默奥大学（Umea University）进行了一个合作研究项目，由MIRAI 2.0 Jiont Seed成立。我领导了对日本和瑞典不同社会经济水平（SES）的生活方式和大脑结构（MRI筛查）变异的分析，以量化解决女性大脑脆弱性的解决方案。主要研究结果发表在美国老年学学会年会上（DOI: 10.1093/geroni/igac059.2909）。这项研究在这两个国家显示了一个相似的参数，即生活方式疾病（糖尿病、高血压、抑郁和肥胖）解释了SES与不同边缘叶区域体积之间的关系。这些发现表明，在专业水平上进行有针对性的疾病管理（即由当地社区提供免费医疗讲座和方便前往医院）是维持老年人认知健康的最可行和有效的策略，特别是对于处于社会经济地位不利的妇女。

Last year, I successfully applied for a visiting fellowship at Michigan State University (Sep 2022 to Feb 2023); where I learned about longitudinal high-dimensional model analysis and the recognized resources of multiple platforms for investigating the interaction of lifestyle with cognitive trajectories (ongoing project). Apart from this project, I am engaged in a collaborative research project with Umea University (Sweden, founded by MIRAI 2.0 Jiont Seed). I led the analysis of lifestyle and brain structure (MRI screening) variants across socioeconomic (SES) levels in Japan and Sweden to quantify solutions to address women's brain vulnerability. Key findings were published at the Annual Meeting of the Gerontology Society of America (DOI: 10.1093/geroni/igac059.2909). This study showed a similar parameter in both countries that lifestyle diseases (diabetes, hypertension, depression and obesity) explained the relationship between SES and the volume of different limbic lobe regions. Such findings suggest that targeted disease management at the professional level (i.e. free medical lectures by the local community and easy access to hospitals) is the most feasible and effective strategy for maintaining cognitive well-being in older adults, especially for women who are SES disadvantaged.