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Intergenerational social mobility and brain cognitive degeneration.

代际社会流动性和大脑认知退化。

基本信息

批准号：
22KJ0276
负责人：
LIU YINGXU
金额：
$ 0.64万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2023
资助国家：
日本
起止时间：
2023-03-08 至 2024-03-31
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KJ0276/
关键词：
Brain vulnerability Social class SES

项目摘要

Last year, I successfully applied for a visiting fellowship at Michigan State University (Sep 2022 to Feb 2023); where I learned about longitudinal high-dimensional model analysis and the recognized resources of multiple platforms for investigating the interaction of lifestyle with cognitive trajectories (ongoing project). Apart from this project, I am engaged in a collaborative research project with Umea University (Sweden, founded by MIRAI 2.0 Jiont Seed). I led the analysis of lifestyle and brain structure (MRI screening) variants across socioeconomic (SES) levels in Japan and Sweden to quantify solutions to address women's brain vulnerability. Key findings were published at the Annual Meeting of the Gerontology Society of America (DOI: 10.1093/geroni/igac059.2909). This study showed a similar parameter in both countries that lifestyle diseases (diabetes, hypertension, depression and obesity) explained the relationship between SES and the volume of different limbic lobe regions. Such findings suggest that targeted disease management at the professional level (i.e. free medical lectures by the local community and easy access to hospitals) is the most feasible and effective strategy for maintaining cognitive well-being in older adults, especially for women who are SES disadvantaged.

去年，我成功申请了密歇根州立大学的访问奖学金（2022年9月至2023年2月）;在那里我了解了纵向高维模型分析和多个平台的公认资源，用于调查生活方式与认知轨迹的相互作用（正在进行的项目）。除此之外，我还与瑞典于默奥大学（由米拉伊2.0 Jiont Seed创立）进行合作研究。我领导了对日本和瑞典社会经济（SES）水平的生活方式和大脑结构（MRI筛查）变体的分析，以量化解决女性大脑脆弱性的解决方案。主要研究结果发表在美国老年学学会年会上（DOI：10.1093/geroni/igac059.2909）。这项研究表明，在这两个国家的生活方式疾病（糖尿病，高血压，抑郁症和肥胖症）解释SES和不同的边缘叶区域的体积之间的关系相似的参数。这些研究结果表明，在专业层面上进行有针对性的疾病管理（即当地社区提供免费医学讲座，方便前往医院）是维持老年人认知健康的最可行和有效的策略，特别是对于处于社会经济地位不利的妇女。