Intergenerational social mobility and brain cognitive degeneration.

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Last year, I successfully applied for a visiting fellowship at Michigan State University (Sep 2022 to Feb 2023); where I learned about longitudinal high-dimensional model analysis and the recognized resources of multiple platforms for investigating the interaction of lifestyle with cognitive trajectories (ongoing project). Apart from this project, I am engaged in a collaborative research project with Umea University (Sweden, founded by MIRAI 2.0 Jiont Seed). I led the analysis of lifestyle and brain structure (MRI screening) variants across socioeconomic (SES) levels in Japan and Sweden to quantify solutions to address women's brain vulnerability. Key findings were published at the Annual Meeting of the Gerontology Society of America (DOI: 10.1093/geroni/igac059.2909). This study showed a similar parameter in both countries that lifestyle diseases (diabetes, hypertension, depression and obesity) explained the relationship between SES and the volume of different limbic lobe regions. Such findings suggest that targeted disease management at the professional level (i.e. free medical lectures by the local community and easy access to hospitals) is the most feasible and effective strategy for maintaining cognitive well-being in older adults, especially for women who are SES disadvantaged.