The research on the rationalization and internationalization of the method of data analysis for preclinical experiments

本研究解决了临床前研究中发现的一些统计问题，如小鼠淋巴瘤试验、转化试验和致突变性试验。提出了一种新的小鼠淋巴瘤实验数据分析方法，结果将提交给《突变研究》。建议在转化试验的验证研究中使用Margolin程序，其结果提交给“实验动物的替代品”。从统计学的角度提出了设计和进行三种体内诱变试验的建议，内容发表在《突变研究》上。

This study addressed some statistical issues realized in pre-clinical studies such as the mouse lymphoma assay, transformation assay, and mutagenicity tests.A new method for data analysis was proposed on the mouse lymphoma assay, the result of which will be submitted to the "Mutation Research". The utilization of a Margolin procedure in a validation study on the transformation assay was proposed, the result of which was submitted to the "Alternatives to Laboratory Animals." A proposal for the design and conduct of three in vivo mutagenicity tests was proposed from the viewpoint of statistics, the content was published on the "Mutation Research."