Development and reexamination of the dentin adhesion system

牙本质粘附系统的开发和复查

• 批准号: 09672005
• 负责人: ARAI Koichi
• 金额: $ 1.02万
• 依托单位: Meikai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672005/
• 关键词: Dentin adhesion; Dentin primer; Bonding agent; Fluoric releasable filler; Composite resin; Adhesion mechanism; Shear bond strength; Photo polymerization-type; 光合型コンポジットレジン; フッ素徐放性; 光重合型コンポジットレンジ

The purpose of this study is to clarify the effect of the experimental dentin primers with 33 kinds of amino acid derivatives and to have added into the bonding agents in case of dentin adhesion, and the bond mechanism.After treating to dentins respectively by the A-primers which added 18 kinds of 0.5mol% aliphatic amino acids and 15 kinds of 0.5mol% aromatic amino acid to 6Owt%HEMA water solution respectively, and B- or C-primers which added 10 wt%4-methacryloxydecyl trimellitic anhydride(4-MHTA) or 10 wt%4-methacryloxydecyl trimellitic anhydride (4-MDTA) which was synthesized respectively, to the A-primer, the bonding agent containing 5 wt% 4-MHTA or 5 wt% 4-MDTA respectively was applied to the dentin, and then a photo polymerization-type composite resin was filled to the dentin.The shear bond strength of the 99 kinds of dentin adhesion systems were examined and compared with the 99 kinds of primers, and the following results were obtained.The shear bond strength of the B-primer was … More showed higher than the A-primer in the identical amino acid, and the value was more than about 1.5 times. The other hand, the shear bond strength of the C-primer was more than about 1.1 times as high value the B-primer in the same ammo acid. In the dentin adhesion system of the C-primer, there were five kinds of aromatic amino acids and eight kinds of the aliphatic amino acids that the bond strength showed about 20 Mpa and a high value.In two kinds of 4-MHTA and 4-MDTA which synthesized, 4-MDTA in that the methylene chain is long, the bond strength was the tendency which becomes higher. Also, even if it added 5-wt% fluoric releasable filler into the experimental bonding agent, the bond strength didn't decrease.It was suggested as for the bond mechanism of the dentin adhesion system with high shear bond strength that (COO-)ィイD22ィエD2 group of 4MDTA was formed the chelate bond to CaィイD22+ィエD2 hydroxyapatite and hydrogen bond to the amino group of the collagen in the dentin as ligand monomer in water. Less

本研究的目的是阐明含有33种氨基酸衍生物的实验牙本质底漆，并加入到粘接剂中，对牙本质粘接的影响，A-引物分别添加18种0.5mol%脂肪族氨基酸和15种0.5mol%芳香族氨基酸至6Owt%，分别将HEMA水溶液和B-或C-底漆分别添加10重量%的4-甲基丙烯酰氧基癸基偏苯三酸酐（4-MHTA）或10重量%的4-甲基丙烯酰氧基癸基偏苯三酸酐（4-MDTA）合成，A-底漆中分别施加含有5重量%的4-MHTA或5重量%的4-MDTA的粘结剂，然后将光聚合型复合树脂填充到牙本质上。测试了99种牙本质粘附系统的剪切粘结强度，并与99种底漆进行了比较，得到了以下结果：B底漆的剪切粘结强度为 ...更多信息 在相同氨基酸上显示高于A引物，且值约为1.5倍以上。另一方面，在相同的氨基酸中，C底漆的剪切粘结强度是B底漆的约1.1倍。在C-primer的牙本质粘接体系中，有5种芳香族氨基酸和8种脂肪族氨基酸的粘接强度均表现为20 Mpa左右的高值，在合成的2种4-MHTA和4-MDTA中，4-MDTA由于亚甲基链较长，粘接强度有变高的趋势。另外，即使在实验粘结剂中加入5重量%的可剥离性填料，高剪切强度的牙本质粘接系统的粘接机理可能是4 MDTA的（COO-）-羧基D22-羧基D2基团与Ca ~（2+）形成螯合键羟基磷灰石和氢键结合到牙本质中的胶原蛋白的氨基作为配体单体在水中。少

项目成果

新井浩一: "試作デンチンプライマーの性能について" 歯科材料・器械. (発表予定).

Koichi Arai：“原型牙本质底漆的性能”牙科材料和仪器（预定演示）。

新井 浩一: "試作デンチンプライマーの性能について"歯科材料・器械. (発表予定).

Koichi Arai：“原型牙本质底漆的性能”牙科材料和仪器（预定演示）。

ARAI,K.: "Development of the dentin adhesion system"J.J. Dent. Mater.. (contribution schedule).

ARAI,K.：“牙本质粘附系统的开发”J.J.

新井浩一: "試作デンチンプライマーの性能について"歯科材料・器械. (発表予定).

Koichi Arai：“原型牙本质底漆的性能”牙科材料和仪器（预定演示）。

新井 浩一: "試作象牙質接着システムの検討" 歯科材料・器械. 発表予定.

Koichi Arai：“牙本质粘附系统原型研究”牙科材料和仪器预定演示。