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Development of Adhesive Primer to Dentin

牙本质粘合底漆的研制

基本信息

批准号：
09672012
负责人：
NISHIYAMA Norihiro
金额：
$ 2.11万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672012/
关键词：
^<13>C NMR Primer Dentinal collagen Interaction Dentin adhesion ^<13>CNMR プロリルプロリルグリシン

项目摘要

Five species of NMomegaA, NMGIy (glycine), NMbetaAla (beta-Valanine), NMBu (gamma-amino butyric acid), NMVa deltaamino valeric acid) and NMCa epsilon-amino caproic acid) were synthesized with the condensation of methacryloyl chloride to the amino group which corresponded to the omega-amino acid in the presence of NaOH.The interaction between NMomegaA primers and dentinal collagen were studied using the ^<13>C NMR technique including the observation of spin-lattice relaxation times, T_1. The effect of the strength of the interaction of the primer to the demineralized dentin on the bond strength of resin to the acid-etched dentin was examined.When the dentinal collagen was dispersed into the NMomegaA solution, the T_1 values of the two carbonyl carbons attributed to the amide and the carboxylic acid in the NMomegaA molecule decreased dramatically. This result was due to the interaction between the amide group and the carboxylic acid group in the NMomegaA molecule and the dentinal collagen molecule. The T_1 value of these carbonyl carbons decreased when the number of methylene in the NMomegaA molecule increased. The interaction became stronger, as the number of methylene in the NMomegaA molecule was increased. Further, the bond strength of the resin to the acid-etched dentin primed with NMomegaA increased with a decrease in the T_1 value of the amide carbonyl carbon. The strength of the interaction of the NMomegaA primer to the dentinal collagen molecule determined by ^<13>C NMR technique showed a direct correlation with the bond strength of the resin to acid-etched dentin that was treated with the NMomegaA primer. The adsorption behavior of the several types of primers onto the demineralized dentin will be discussed by using ^<113>C NMomegaR technique. Because the NMomegaR technique is very sensitive to investigate the several types of interaction.

采用甲基丙烯酰氯与ω-氨基酸的氨基在NaOH存在下缩合的方法合成了5种NMomegaA、NMGGly（甘氨酸）、NMbetaAla（β-缬氨酸）、NMBu（γ-氨基丁酸）、NMVa（δ-氨基戊酸）和NMCa（ε-氨基己酸），用~ 13 C NMR技术研究了NMomegaA引物与牙本质胶原的相互作用<13>，包括自旋-晶格弛豫时间T_1的观测。当牙本质胶原分散在NMomegaA溶液中时，NMomegaA分子中的酰胺和羧酸的两个羰基碳的T_1值显著降低，当牙本质胶原分散在NMomegaA溶液中时，NMomegaA分子中的酰胺和羧酸的两个羰基碳的T_1值显著降低。这一结果是由于NMomegaA分子和牙本质胶原分子中的酰胺基团和羧酸基团之间的相互作用。这些羰基碳的T_1值随着NMomegaA分子中亚甲基数目的增加而降低。随着NMomegaA分子中亚甲基数目的增加，相互作用变得更强。此外，树脂与酸蚀牙本质的粘结强度随着酰胺羰基碳的T_1值的降低而增加。通过13 C NMR技术测定的NMomegaA引物与牙本质胶原分子的相互作用的强度<13>显示出与树脂与用NMomegaA引物处理的酸蚀牙本质的结合强度直接相关。本文用~（13）CNMomegaR技术研究了几种引物在脱矿牙本质上的吸附行为<113>。因为NMomegaR技术对于研究几种类型的相互作用非常敏感。