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Development of Dentin Bonding System

牙本质粘接系统的开发

基本信息

批准号：
16390565
负责人：
NISHIYAMA Norihiro
金额：
$ 8.26万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390565/
关键词：
Self-etching primer Tooth bonding Interaction NMR Degradation Bond durabili 加水分解安定性変質 ^<13>C NMR 接着脱灰機構 ^<13>C NMR法

项目摘要

In this study, a series of five ED Primer II Liquid A primers in different stages of degradation, where the HEMA employed in the Liquid A primer had been hydrolyzed by 4.7,39.2,61.9,66.7 and 66.8 %, respectively, were prepared. The degradation stage effects of the ED Primer II Liquid A primers used for resin core restoration, on the dentin bond durability were examined. The initial shear bond strength remained unchanged at approximately 12 MPa until the degradation stages of the altered Liquid A primers ranged from 4.7 to 61.9 %, even though the quality of the resin hybridized collagen layer had decreased. However, the application of thermo-cycling resulted in specific decreases in the bond strength and degradation of the resin hybridized collagen layer. The degree of reduction in the bond strength was strongly dependent on the degradation stage of the hydrolyzed Liquid A primer.Furthermore, three experimental self-etching primers - consisting of NMωR with different methylene chain lengths and NMGIy - were developed. This was done with a view to investigating the effect of methylene chain length in NMωP derivatives on the chemical nature of calcium salts, as well as its effect on the bond strengths of resin to enamel and dentin. NMR analysis data showed that NMωPs decalcified tooth components with formation of calcium salts, which changed from calcium hydrogen phosphonate to calcium phosphonate with increase in methylene chain length within the NMωP structure. Disparity in calcium salt formation was related to increases in bond strength to enamel from 18 to 24 MPa, reflecting an increase in the hydrophobicity of NMωP calcium salt. However, bond strength to dentin remained unchanged at approximately 22 MPa. This difference probably arose from the dissimilar locations at which NMωP calcium salts were deposited on enamel and dentin.

在这项研究中，制备了一系列五种处于不同降解阶段的艾德底漆II液体A底漆，其中液体A底漆中使用的HEMA分别水解了4.7%、39.2%、61.9%、66.7%和66.8%。研究了艾德Primer II Liquid A型树脂核修复用底漆的降解阶段对牙本质粘结耐久性的影响。初始剪切粘合强度保持不变，约为12 MPa，直到改变的液体A底漆的降解阶段范围为4.7 - 61.9%，即使树脂杂交胶原层的质量已经降低。然而，热循环的应用导致特定的粘合强度降低和树脂杂交胶原层的降解。粘接强度的降低程度与水解液A底漆的降解阶段密切相关。此外，开发了三种实验性自酸蚀底漆-由具有不同亚甲基链长度的NMωR和NMGIy组成。目的是研究NMωP衍生物中亚甲基链长对钙盐化学性质的影响，以及对树脂与牙釉质和牙本质结合强度的影响。NMR分析数据表明，NMωPs脱钙形成的钙盐，从磷酸氢钙到磷酸钙的变化与NMωP结构中的亚甲基链长度的增加。钙盐形成的差异与从18到24 MPa的牙釉质粘结强度的增加有关，反映了NMωP钙盐疏水性的增加。然而，与牙本质的粘结强度保持不变，约为22 MPa。这种差异可能是由于NMωP钙盐在牙釉质和牙本质上沉积的位置不同所致。