Development of tooth adhesive system based on methacrylamide

自蚀刻底漆的应用增强了树脂-牙界面的结合。之前，我们研究了n -甲基丙烯酰- ω -氨基酸（NMomegaA）作为自蚀刻底漆的功能单体的蚀刻和引物效果。NMomegaA的羧酸能使牙釉质和牙本质脱矿。NMomegaA溶液在牙本质上的应用使树脂的结合强度提高到20 MPa以上。相反，NMomegaA与牙釉质的最大结合强度仅为16 MPa，这是因为NMomegaA中的羧酸限制了牙釉质的脱矿作用。在本研究中，为了提高树脂与牙釉质的结合强度，我们合成了n -甲基丙烯酰-3-氨基乙基膦酸NMEP作为酸性单体，并设计了n -甲基丙烯酰甘氨酸NMGly-NMEP自蚀刻胶粘剂。研究了在NMGly-NMEP溶液中增加NMEP的添加量对牙齿脱矿的影响及其对牙齿结合强度的影响。将NMGly-NMEP溶液应用于牙釉质，当在NMGly水溶液中添加额外量的NMEP时，牙釉质的结合强度从16 MPa增加到24 MPa。这种增加是由于NMEP中的膦酸使牙釉质脱矿。相反，在NMGly溶液中加入NMEP会导致与牙本质的结合强度下降。NMEP在NMGly-NMEP溶液中的最佳浓度使牙本质和牙釉质的结合强度均超过20 MPa。

It is well understood that the application of a self-etching primer enhances the bonding at the resin-teeth interface.Previously, we examined the etching and priming efficacies of the N-methacryloyl-omega-amino acid, NMomegaA as a functional monomer for a self-etching primer. The carboxylic acid of the NMomegaA demineralized the enamel and dentin. The application of the NMomegaA solution to the dentin increased the bond strength of the resin to over 20 MPa. Conversely, the maximum bond strength to the enamel was only 16 MPa, since the demineralization of the enamel was limited by the carboxylic acid in the NMomegaA.In this study, in order to increase the bond strength of the resin to the enamel, we synthesized the N-methacryloyl-3-aminoethyl phosphonic acid, NMEP as an acidic monomer and designed an N-methacryloyl glycine, NMGly-NMEP self-etching adhesive. The effects of increasing the amounts of NMEP added to the NMGly-NMEP solution had on the demineralization of the tooth and its effects on the bond strength to the tooth were examined.The application of the NMGly-NMEP solution to the enamel resulted in an increase in the bond strength from 16 MPa to 24 MPa when additional amounts of NMEP were added to the NMGly aqueous solution. This increase was due to the phosphonic acid in the NMEP demineralizing the enamel. Conversely, the addition of the NMEP to the NMGly solution resulted in a decrease in the bond strength to the dentin. The optimal concentration of the NMEP in the NMGly-NMEP solution resulted in bond strengths of over 20 MPa for both the enamel and dentin.