Development of tooth adhesive system based on methacrylamide

基于甲基丙烯酰胺的牙齿粘合系统的开发

• 批准号: 13470421
• 负责人: NISHIYAMA Norihiro
• 金额: $ 8.9万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470421/
• 关键词: Self-etching primer; Methacrylamide; ^<13>C NMR; Bond strength; Demineralization; 相互作用

It is well understood that the application of a self-etching primer enhances the bonding at the resin-teeth interface.Previously, we examined the etching and priming efficacies of the N-methacryloyl-omega-amino acid, NMomegaA as a functional monomer for a self-etching primer. The carboxylic acid of the NMomegaA demineralized the enamel and dentin. The application of the NMomegaA solution to the dentin increased the bond strength of the resin to over 20 MPa. Conversely, the maximum bond strength to the enamel was only 16 MPa, since the demineralization of the enamel was limited by the carboxylic acid in the NMomegaA.In this study, in order to increase the bond strength of the resin to the enamel, we synthesized the N-methacryloyl-3-aminoethyl phosphonic acid, NMEP as an acidic monomer and designed an N-methacryloyl glycine, NMGly-NMEP self-etching adhesive. The effects of increasing the amounts of NMEP added to the NMGly-NMEP solution had on the demineralization of the tooth and its effects on the bond strength to the tooth were examined.The application of the NMGly-NMEP solution to the enamel resulted in an increase in the bond strength from 16 MPa to 24 MPa when additional amounts of NMEP were added to the NMGly aqueous solution. This increase was due to the phosphonic acid in the NMEP demineralizing the enamel. Conversely, the addition of the NMEP to the NMGly solution resulted in a decrease in the bond strength to the dentin. The optimal concentration of the NMEP in the NMGly-NMEP solution resulted in bond strengths of over 20 MPa for both the enamel and dentin.

众所周知，自酸蚀底漆的应用增强了树脂-牙齿界面处的粘结。之前，我们检查了N-甲基丙烯酰基-ω-氨基酸，NMomegaA作为自酸蚀底漆的功能单体的蚀刻和底漆功效。NMomegaA的羧酸使牙釉质和牙本质脱矿。将NMomegaA溶液应用于牙本质将树脂的粘结强度增加到20 MPa以上。在本研究中，为了提高树脂与牙釉质的粘结强度，我们合成了N-甲基丙烯酰基-3-氨基乙基膦酸，NMEP作为酸性单体，并设计了一种N-甲基丙烯酰基甘氨酸，NMGly-NMEP自酸蚀粘合剂。研究了增加加入到NMGly-NMEP溶液中的NMEP的量对牙齿脱矿的影响及其对牙齿粘结强度的影响，当将额外量的NMEP加入到NMGly水溶液中时，将NMGly-NMEP溶液施用于牙釉质导致粘结强度从16 MPa增加到24 MPa。这种增加是由于NMEP中的膦酸使釉质脱矿。相反，将NMEP添加到NMGly溶液中导致与牙本质的粘结强度降低。NMGly-NMEP溶液中NMEP的最佳浓度导致牙釉质和牙本质的粘结强度均超过20 MPa。

项目成果

N.Nishiyama, et al.: "The pKa effects of the Carboxylic Acid in N-Methacryloyl-omega-Amino Acid on the Demineralization and Bond Strengths to the Teeth"Biomatarials. 25-23. 5441-5447 (2004)

N.Nishiyama 等人：“N-甲基丙烯酰-omega-氨基酸中的羧酸对牙齿脱矿质和粘合强度的 pKa 影响”生物材料。

N.Nishiyama, et al.: "Hydrolytic Stability of Methacrylamide in Acidic Aqueous Solution"Biomaterials. 25・6. 965-969 (2004)

N. Nishiyama等：“酸性水溶液中甲基丙烯酰胺的水解稳定性”生物材料965-969。

N.Nishiyama, et al.: "The pKa effects of the Carboxylic Acid in N-Methacryloyl-omega-Amino Acid on the Demineralization and Bond Strengths to the Teeth"Biomaterials. 25・23. 5441-5447 (2004)

N. Nishiyama 等：“N-甲基丙烯酰-omega-氨基酸中的 pKa 对牙齿脱矿质和粘合强度的影响”生物材料 5441-5447。

H.Yoshida, et al.: "Development of Self-etching Primer Comprised of Methacrylamide, N-Methacryloyl Glycine"Biomaterials. 24(28). 5203-5207 (2003)

H.Yoshida等人：“由甲基丙烯酰胺、N-甲基丙烯酰甘氨酸组成的自蚀刻底漆的开发”生物材料。

N.Nishiyama, et al.: "The pKa effects of the Carboxylic Acid in N-Methacryloyl-omega-Amino acid on the Demineralization and Bond Strengths to the Teeth"Biomaterials. (printing). (2004)

N.Nishiyama 等人：“N-甲基丙烯酰-omega-氨基酸中的羧酸对牙齿脱矿质和粘合强度的 pKa 影响”生物材料。