Application of silver-inorganic anti-microbial reagent for prosthodontic field

银无机抗菌试剂在口腔修复领域的应用

• 批准号: 09672011
• 负责人: TANAKA Takaaki
• 金额: $ 0.96万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672011/
• 关键词: silver-inorganic anti-microbial reagent; anti-microbial prosthesis; oral microorganisms; 銀系無機抗菌剤; Actinomyces viscosus; 抗菌作用; 口腔内細菌; 抗菌剤; 付着; プラーク

The effect of silver-inorganic anti-microbial reagent (ION PURE^<TM> and NOBARON^<TM>) on oral microorganisms were examined.1. Minimam inhibitory concentration (MIC) of anti-microbial reagent (ION PURE^<TM> and NOBARON^<TM>) for S.mutans was 7.5mg/ml and1.3mg. The antimicrobial action was bacteriostatic one. The resin plate thatcontaining both anti-microbial reagent showed remarkably reduced the microorganisms on its plate.2. MIC of NOBARON'TM for C.albicans was 500 mug/ml, and the bacterial action was candidacidal one.Denture containing 5wt% NOBARON^<TM> showed a remarkable decrease in the amount of Candida coloniesby imprint culture method.3.1) The contact angle of three coating materials (429R,740 and Brightener^<TM>) was 37.8 degree, 28.9 degree and 27.9 degree on self- curing acrylic resin, and that specific gravity was 1 .00, 1.04 and 1.07. Brightener^<TM> showed high knoop hardness within three material. For elementary analysis, Brightener^<TM> containing anti-microbial reagent has more Ag intensity than thats of self-curing acrylic resin.2) MIC of anti-microbial reagent (ION PURE^<TM> and NOBARON^<TM>) for A.viscosus was 2.5mg/ml and 1.3mg/ml. Brightener^<TM> containing the reagent has more anti-microbial effect than other coating materials.

观察银无机抗微生物试剂ION PURE^<TM>和NOBARON^<TM>对口腔微生物的影响。抗菌试剂ION PURE^<TM>和NOBARON^<TM>对变形链球菌的最小抑制浓度（MIC）分别为7.5mg/ml和1.3mg。抗菌作用为抑菌作用。含有两种抗微生物试剂的树脂板对其板上的微生物有显著的抑制作用。NOBARON tm对白色念珠菌的MIC为500马克/毫升，抑菌作用为候选菌作用。含5wt% NOBARON^<TM>的义齿经压印培养后，念珠菌菌落数量明显减少。3.1)三种涂层材料（429R、740和光亮剂^<TM>）与自固化丙烯酸树脂的接触角分别为37.8度、28.9度和27.9度，比重为1。00, 1.04和1.07。增白剂^<TM>在三种材料中表现出较高的努氏硬度。元素分析表明，含抗菌剂的增白剂比自固化丙烯酸树脂具有更高的银强度。2)抗菌试剂ION PURE^<TM>和NOBARON^<TM>对粘菌的MIC分别为2.5mg/ml和1.3mg/ml。含该试剂的增白剂比其他涂料具有更好的抗菌效果。

项目成果

小林平: "銀系無機抗菌剤の補綴領域への応用" 日本補綴歯科学会雑誌. 41・特別号. 54-54 (1997)

Taira Kobayashi：“银基无机抗菌剂在修复领域的应用”日本修复医学会杂志41/特刊54-54（1997）。