Application of silver-inorganic anti-microbial reagent for prosthodontic field

研究了银-无机抗菌剂（ION PURE^<TM>和NOBARON^<TM>）对口腔微生物的影响.抗菌药物ION PURE<TM>和NOBARON<TM>对变形链球菌的最低抑菌浓度分别为7.5mg/ml和1.3mg/ml。抗菌作用为抑菌作用。同时含有两种抗菌剂的树脂平板，其平板上的微生物数量明显减少. NOBARON TM对白色念珠菌的MIC为500 μ g/ml，具有杀菌作用。用压印培养法测得含5wt%NOBARON TM的涂膜<TM>对念珠菌菌落数有显著的减少作用。3.1）三种涂膜材料（429 R、740和Brightener TM<TM>）在自凝丙烯酸树脂上的接触角分别为37.8度、28.9度和27.9度，比重分别为1.00、1.04和1.07。增白剂<TM>在三种材料中均表现出较高的努普硬度。2<TM>）抗菌剂ION PURE和NOBARON对粘性放线菌的MIC<TM>分别<TM>为2.5mg/ml和1.3mg/ml。含有该试剂的增白剂<TM>比其他涂层材料具有更好的抗菌效果。

The effect of silver-inorganic anti-microbial reagent (ION PURE^<TM> and NOBARON^<TM>) on oral microorganisms were examined.1. Minimam inhibitory concentration (MIC) of anti-microbial reagent (ION PURE^<TM> and NOBARON^<TM>) for S.mutans was 7.5mg/ml and1.3mg. The antimicrobial action was bacteriostatic one. The resin plate thatcontaining both anti-microbial reagent showed remarkably reduced the microorganisms on its plate.2. MIC of NOBARON'TM for C.albicans was 500 mug/ml, and the bacterial action was candidacidal one.Denture containing 5wt% NOBARON^<TM> showed a remarkable decrease in the amount of Candida coloniesby imprint culture method.3.1) The contact angle of three coating materials (429R,740 and Brightener^<TM>) was 37.8 degree, 28.9 degree and 27.9 degree on self- curing acrylic resin, and that specific gravity was 1 .00, 1.04 and 1.07. Brightener^<TM> showed high knoop hardness within three material. For elementary analysis, Brightener^<TM> containing anti-microbial reagent has more Ag intensity than thats of self-curing acrylic resin.2) MIC of anti-microbial reagent (ION PURE^<TM> and NOBARON^<TM>) for A.viscosus was 2.5mg/ml and 1.3mg/ml. Brightener^<TM> containing the reagent has more anti-microbial effect than other coating materials.