Study of the sleep disturbances after anesthesia or operation

手术后睡眠受到抑制。然而，术后睡眠障碍的机制尚不清楚。我们假设麻醉药或促睡眠细胞因子与术后睡眠障碍有关。因此，我们研究了氯胺酮和挥发性麻醉药异氟醚对家兔睡眠的影响。氯胺酮增加非快速眼动睡眠（NREMS）和脑电图慢波活动。相反，异氟醚降低了NREMS。这些结果表明，挥发性麻醉药而非氯胺酮可能加重术后睡眠障碍。此外，我们还研究了肿瘤坏死因子与白细胞介素-1之间的促睡眠关系。在本研究中，我们发现肿瘤坏死因子和白细胞介素-1在调节生理性睡眠和病理性睡眠中有着密切的联系。由于手术刺激了细胞因子网络，这些促睡因子可能与术后睡眠障碍有关。

Sleep is inhibited after operation. However, the mechanism of postoperative sleep disturbance is not well known. We hypothesized that anesthetics or somnogenic cytokine is involved in the postoperative sleep disturbances. Therefore, we studied the effects of an intravenous anesthetic agent, ketamine and a volatile anesthetic drug, isoflurane on sleep in rabbits. Ketamine increased non-rapid-eye-movement sleep (NREMS) and electroencephalogram slow wave activity. In contrast, isoflurane reduced NREMS. These results suggest that volatile anesthetics but not ketamine may enhance the postoperative sleep disturbance. Furthermore, we studied that the somnogenic relationships between tumor necrosis factor and interleukin-1. In this study, we found that tumor necrosis factor and interleukin-1 are closed linked to regulate physiological sleep and pathological sleep. Since operation stimulates cytokine network, these somnogenic cytokines should be related to postoperative sleep disturbances.