Study of the sleep disturbances after anesthesia or operation

麻醉或手术后睡眠障碍的研究

• 批准号: 09671533
• 负责人: TAKAHASHI Satoshi
• 金额: $ 2.37万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671533/
• 关键词: Anesthesia; operation; sleep; ketamine; isoflurane; Cytokine; TNF; interleukin; 睡眠; イソフルレン; インターロイキン-1; 腫瘍壊死因子; 手術侵襲; インターロイキン1; 脳波; 筋電

Sleep is inhibited after operation. However, the mechanism of postoperative sleep disturbance is not well known. We hypothesized that anesthetics or somnogenic cytokine is involved in the postoperative sleep disturbances. Therefore, we studied the effects of an intravenous anesthetic agent, ketamine and a volatile anesthetic drug, isoflurane on sleep in rabbits. Ketamine increased non-rapid-eye-movement sleep (NREMS) and electroencephalogram slow wave activity. In contrast, isoflurane reduced NREMS. These results suggest that volatile anesthetics but not ketamine may enhance the postoperative sleep disturbance. Furthermore, we studied that the somnogenic relationships between tumor necrosis factor and interleukin-1. In this study, we found that tumor necrosis factor and interleukin-1 are closed linked to regulate physiological sleep and pathological sleep. Since operation stimulates cytokine network, these somnogenic cytokines should be related to postoperative sleep disturbances.

手术后睡眠受到抑制。然而，术后睡眠障碍的机制还不清楚。我们推测麻醉剂或致眠细胞因子与术后睡眠障碍有关。因此，我们研究了静脉麻醉药氯胺酮和挥发性麻醉药异氟醚对家兔睡眠的影响。氯胺酮增加非快速眼动睡眠（NREMS）和脑电图慢波活动。相反，异氟烷降低NREMS。这些结果表明，挥发性麻醉药，而不是氯胺酮可能会增加术后睡眠障碍。此外，我们还研究了肿瘤坏死因子和白细胞介素-1与睡眠的关系。本研究发现肿瘤坏死因子和白细胞介素-1在调节生理性睡眠和病理性睡眠中有密切联系。由于手术刺激细胞因子网络，这些致眠细胞因子可能与术后睡眠障碍有关。

项目成果

Takahashi S, et al.: "Bispectral index periodically changes during spontaneous sleep in man."Anesthesia and Analgesia. 86. S234 (1998)

Takahashi S 等人：“脑电双频指数在人类自发睡眠期间周期性变化。”麻醉和镇痛。

Satoshi Takahashi: "Ketamine alters sleep in rabbits"New Balanced Anesthesia. 1. 277-278 (1998)

Satoshi Takahashi：“氯胺酮改变兔子的睡眠”新平衡麻醉。

高橋敏: "眠りのバイオロジー:われわれはなぜ眠るか 催眠のメカニズムからみた麻酔"イディカル・サイエンス・インターナショナル. 123 (1998)

Satoshi Takahashi：“睡眠生物学：我们为什么睡觉？从催眠机制的角度看麻醉” Idical Science International 123 (1998)。

Satoshi Takahashi: "Bispectral index periodically changes during spowtaneous sleep in man"Anesthesia and Andlgesia. 86. S234-234 (1998)

Satoshi Takahashi：“双频指数在人类自发睡眠期间周期性变化”麻醉和痛觉。

Takahashi S, et al.: "Inhibition of tumor necrosis factor and interleukin-1 attenuates physiological sleep in rabbits."Society for neuroscience abstracts. 24. 938 (1998)

Takahashi S 等人：“肿瘤坏死因子和白介素-1 的抑制会减弱兔子的生理睡眠。”神经科学协会摘要。