Identification of novel growth factor for Glioma cancer stem cells
Identification of novel growth factor for Glioma cancer stem cells
批准号:
21791377
负责人:
TAKAHASHI Satoshi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
我们的研究目的是寻找胶质瘤肿瘤干细胞的新型生长因子,并确定了KIF23和uPARAP。KIF23在胶质瘤细胞中的下调抑制其增殖。胶质瘤细胞中uPARAP的下调通过改变肌动蛋白细胞骨架抑制胶质瘤细胞的迁移和侵袭特性。我们还在蛋白水平上证实了这两种分子在神经胶质瘤干细胞中的表达。
英文摘要
We have conducted our research for the purpose of identifying novel growth factors for glioma cancer stem cells, and identified KIF23 and uPARAP. Downregulation of KIF23 in glioma cells suppressed their proliferation. Downregulation of uPARAP in glioma cells suppressed migration and invasion properties of glioma cells through changes in actin cytoskeleton. We have also confirmed the expressions of the both molecules in glioma cancer stem cells at protein level.
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P.002 Down-regulation of membrane protein uPARAP makes glioma cells immobile and can be a target for novel glioma therapy
P.002 膜蛋白 uPARAP 的下调使神经胶质瘤细胞无法移动,可以成为新型神经胶质瘤治疗的靶点
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[S.Takahashi, T.Kawase, M.Toda]
通讯作者:
M.Toda
Down-regulation of membrane protein uPARAP makes glioma cells immobile and can be a target for novel glioma therapy
膜蛋白 uPARAP 的下调使神经胶质瘤细胞无法移动,可以成为新型神经胶质瘤治疗的靶点
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Takahashi S, Kawase T, Toda M]
通讯作者:
Toda M
脳腫瘍幹細胞・グリオーマ共通抗原の発現および機能解析
脑肿瘤干细胞/胶质瘤共同抗原的表达及功能分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[戸田正博, 田伏将尚, 大多茂樹, 深谷雷太, 高橋里史, 吉田一成]
通讯作者:
吉田一成
RNA interference-mediated down-regulation of uPARAP decreases invasion and migration property in glioma cells through reorganization of the actin cytoskeleton.
RNA 干扰介导的 uPARAP 下调通过肌动蛋白细胞骨架的重组降低神经胶质瘤细胞的侵袭和迁移特性。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Takahashi S, Toda M, Yamada-Okabe H, Hamada K, Kawase T, Yoshida K]
通讯作者:
Yoshida K
siRNAを用いたuPARAP knock downはGlioma培養細胞の移動・浸潤能を抑制する
使用 siRNA 敲低 uPARAP 抑制神经胶质瘤培养细胞的迁移和侵袭能力
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[高橋里史, 河瀬斌, 戸田正博]
通讯作者:
戸田正博
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