Expression and function analyses of uPARAP in glioma and glioma cancer stem cells
Expression and function analyses of uPARAP in glioma and glioma cancer stem cells
批准号:
19791011
负责人:
TAKAHASHI Satoshi
金额:
$2.42万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
uPARAPはmRNAレベル、タンパクレベルにおいて正常脳に比べて神経膠腫で高発現していた。uPARAPを特異的にknock downするsiRNAをデザインし、神経膠腫cell lineにおけるuPARAPの機能解析を行った結果、同分子が神経膠腫の移動及び浸潤に関与している事が明らかになった。以上より同分子が浸潤能抑制による治療標的となる可能性が示唆された。また、腫瘍幹細胞でもその発現が確認されたため、腫瘍幹細胞を標的とした治療に対する可能性も示唆された。
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