Resolving genomic sexual conflicts via sexually dimorphic gene expression

通过性二态性基因表达解决基因组性冲突

• 批准号: DP150100093
• 负责人: Prof Stephen Chenoweth
• 金额: $ 25.84万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150100093
• 关键词: Resolving; genomic; sexual; conflicts; via

Using powerful genomic technology this project aims to assess the strength of regulatory constraints between males and females and determine whether cis-regulatory mutations help to resolve them. Sex-differences in traits like morphology, behaviour and disease susceptibility often involve sex-differences in the regulation of gene expression. To achieve optimal performance, males and females must express their genes at different levels. Theory and data suggest that for some genes this is not possible, and that males and females could each achieve higher performance if gene regulation became genetically uncoupled between them. It has been suggested that cis-regulatory mutations may be important for resolving regulatory incompatibilities within the genome.

利用强大的基因组技术，该项目旨在评估男性和女性之间的监管约束的强度，并确定顺式调控突变是否有助于解决这些问题。形态、行为和疾病易感性等性状的性别差异往往涉及基因表达调控的性别差异。为了达到最佳表现，男性和女性必须在不同的水平上表达他们的基因。理论和数据表明，对于某些基因来说，这是不可能的，如果基因调控在基因上解耦，男性和女性都可以获得更高的表现。有人建议，顺式调控突变可能是重要的解决基因组内的监管不兼容性。