Resolving genomic sexual conflicts via sexually dimorphic gene expression

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Using powerful genomic technology this project aims to assess the strength of regulatory constraints between males and females and determine whether cis-regulatory mutations help to resolve them. Sex-differences in traits like morphology, behaviour and disease susceptibility often involve sex-differences in the regulation of gene expression. To achieve optimal performance, males and females must express their genes at different levels. Theory and data suggest that for some genes this is not possible, and that males and females could each achieve higher performance if gene regulation became genetically uncoupled between them. It has been suggested that cis-regulatory mutations may be important for resolving regulatory incompatibilities within the genome.