Immunohistological Studies about the Role of betaig-h3 during the Wound Healing of the Corncal Stroma

我们研究了原发性内皮营养不良（Fuchs内皮营养不良）和继发性大疱性角膜病变的组织病理学。光镜下在上皮与鲍曼层之间可见金附加层。电镜检查显示基底膜和纤维组织增厚，有时在一些标本的额外层中有基底膜的增殖。富氏角膜营养不良和手术诱导的大疱性角膜病变之间没有区别。大疱性角膜病变的上皮下组织可能是由上皮细胞和间质细胞迁移到病变角膜的上皮下区域形成的。BK角膜的这种形态异常可能导致上皮脱离并形成大疱。β - ig-h3被认为有助于上皮和鲍曼层的粘附，该蛋白的功能障碍导致上皮紊乱。为了寻找新蛋白β - ig-h3的临床应用，本研究重点研究了最常见的锥形上皮疾病大疱性角膜病变的病理。

We studied the histopathology of both the primary eudothelial dystrophic (Fuchs' endothelial dystrophy) and the secondary induced bullous keratopathy conreas. Au additional layer was seen between the epithelium and Bowman's layer by the light microscopy. Examination of electron microscopy showed thickened basement membrane and fibrous tissue, and sometimes multiplication of the basement membrane in the extra layer in some specimens. There is no difference between the Fuchs' dystrophic corneas and surgically induced bullous keratopathy corneas. The subepithelial tissue of bullous keratopathy corneas may be formed by epithelium and stromal cells that have migrated into the subepithelial area of the diseased corneas. This morphological abnormality in the BK corneas may induce the detachment of the epithelium and form the bullac. beta ig-h3 is supposed to contribute to the adhesion of the epithelium and the Bowman's layer, and the disfunction of the protein causes the epithelial disturbance. To search for the clinical application of the novel protein, beta ig-h3, This study focused on the pathology of the bullous keratopathy corneas which is the most common conical epithelial disorder.