Immunohistological Studies about the Role of betaig-h3 during the Wound Healing of the Corncal Stroma

我们研究了原发性内皮营养不良（Fuchs' endothelial dystrophy）和继发性大泡性角膜病变角膜的组织病理学。光镜下见上皮与Bowman层之间有Au附加层。电镜下可见基底膜和纤维组织增厚，部分标本外层基底膜增生。Fuchs的营养不良角膜和手术诱导的大泡性角膜病变角膜之间没有差异。大泡性角膜病变角膜的上皮下组织可由上皮细胞和已迁移到患病角膜的上皮下区域的基质细胞形成。BK角膜的这种形态学异常可能导致上皮脱落并形成泡状突起。β ig-h3被认为有助于上皮和Bowman层的粘附，并且该蛋白的功能障碍引起上皮紊乱。为了探索β ig-h3蛋白的临床应用，本研究对大泡性角膜病变这一最常见的角膜圆锥上皮病变进行了病理学研究。

We studied the histopathology of both the primary eudothelial dystrophic (Fuchs' endothelial dystrophy) and the secondary induced bullous keratopathy conreas. Au additional layer was seen between the epithelium and Bowman's layer by the light microscopy. Examination of electron microscopy showed thickened basement membrane and fibrous tissue, and sometimes multiplication of the basement membrane in the extra layer in some specimens. There is no difference between the Fuchs' dystrophic corneas and surgically induced bullous keratopathy corneas. The subepithelial tissue of bullous keratopathy corneas may be formed by epithelium and stromal cells that have migrated into the subepithelial area of the diseased corneas. This morphological abnormality in the BK corneas may induce the detachment of the epithelium and form the bullac. beta ig-h3 is supposed to contribute to the adhesion of the epithelium and the Bowman's layer, and the disfunction of the protein causes the epithelial disturbance. To search for the clinical application of the novel protein, beta ig-h3, This study focused on the pathology of the bullous keratopathy corneas which is the most common conical epithelial disorder.