Development of Environmentally Benign Biaryl Couplings Based on Nickel Catalysts

点击翻译按钮获取中文摘要

We have developed nickel-catalyzed oxidative direct biaryl couplings of heteroarenes with arylsilanes and arylboronic acids via C-H bond cleavage. The above catalysis enables the halogen-free construction of biaryl structures. Relevant new transformations of heteroarenes such as direct alkynylation, allylation, and alkylation were also achieved. Moreover, we succeeded in the copper-mediated dehydrogenative cross-biaryl couplings via two-fold C-H cleavage.