MATRIX METALLOPROTEINASE IN TRABECULAR MESHYWORK

小梁网中的基质金属蛋白酶

• 批准号: 09671807
• 负责人: MIYAGAWA Shin-ichi
• 金额: $ 2.24万
• 依托单位: KUMAMOTO UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671807/
• 关键词: matrix metalloproteinase; inflammatory cytokines; keratocyte; superoxide dismutase; 前房隅角; 線維柱帯; matrix metalloproteinase; 前房中; 前房隅角組織; 前房水

We previously reported that pseudomonas elasetse, alkaline protease, exotoxinA, and LPS, all enhanced the release of both matrix metalloproteinase (MMP)-2 and MMP-9 from cultured rabbit keratocytes. In his study we indicated that inflammatory cytokines (TFN-a, IL-1b) also enhanced the release of the MMPs from cultured rabbit keratocyte.We also confirmed inhibitory effects of superoxide dismutase (SOD) on polymorphonuclear leukocyte(PMN)-induced damage of corneal tissue in guinea pigs. The inhibitory effects of SOD were indicated that corneal damage may be induced by superoxide derived from infiltrating PMN as well as MMPs from keratocyte.

我们以前报道过，假单胞菌弹性蛋白酶、碱性蛋白酶、外毒素A和LPS都能促进培养的兔角膜基质细胞释放基质金属蛋白酶（MMP）-2和MMP-9。本研究还证实了炎性细胞因子（TFN-a、IL-1b）对培养的兔角膜基质细胞释放MMPs的促进作用，以及超氧化物歧化酶（SOD）对中性粒细胞（PMN）诱导的豚鼠角膜组织损伤的抑制作用。超氧化物歧化酶（SOD）的抑制作用表明，浸润的中性粒细胞（PMN）产生的超氧化物以及角膜细胞产生的基质金属蛋白酶（MMPs）可能会引起角膜损伤。

项目成果

TAMANI SATOU, SHIN-ICHI MIYAGAWA: "SURGICAL PROCEDURE FOR RHEGMA TOGENEOUS RETINAL DETACHMENT IN GLAUCOMATOU EYES"GANKA. 41. 1175-1162 (1999)

Tamani Satou、Shin-ichi Miyagawa：“青光眼眼视网膜同质性脱离的手术程序”GANKA。

KOKI MATSUMOTO, et al.: "LECITHIN-BOUND SUPER DISMUTASE IN THE PREVENTION OF NEUTROPHIL-INDUCED CORNEAL DAMAGE"INVEST OPHTHALMOL VIS SCI. 39. 30-35 (1998)

KOKI MATSUMOTO 等人：“卵磷脂结合超级歧化酶可预防中性粒细胞引起的角膜损伤”INVEST OPHTHALMOL VIS SCI。

宮川真一: "緑内障眼に生じた裂孔原性網膜剥離に対する手術治療"眼科. 41. 1157-1162 (1999)

Shinichi Miyakawa：“青光眼孔源性视网膜脱离的手术治疗”眼科。 41. 1157-1162 (1999)

Koki Matsumoto: "Lectin-Bound Superoxide Dismutase in the Prevention of neutrophil - Induced pamage of Corneal tissue"Invest ophthalmol Vis Sci. 39. 30-35 (1998)

Koki Matsumoto：“凝集素结合超氧化物歧化酶预防中性粒细胞 - 诱导的角膜组织损伤”Invest olookingmol Vis Sci。