MATRIX METALLOPROTEINASE IN TRABECULAR MESHYWORK

我们先前报道，弹性假单胞菌、碱性蛋白酶、外毒素A和脂多糖都能促进培养的兔角膜基质细胞释放基质金属蛋白酶-2和基质金属蛋白酶-9。在他的研究中，我们发现炎性细胞因子(TFN-a、IL-1b)也能促进培养的兔角膜细胞释放MMPs。我们还证实了超氧化物歧化酶(SOD)对多形核白细胞(PMN)诱导的豚鼠角膜组织损伤的抑制作用。超氧化物歧化酶的抑制作用表明，角膜损伤可能是由PMN和角质形成细胞产生的MMPs和PMN产生的超氧化物歧化所致。

We previously reported that pseudomonas elasetse, alkaline protease, exotoxinA, and LPS, all enhanced the release of both matrix metalloproteinase (MMP)-2 and MMP-9 from cultured rabbit keratocytes. In his study we indicated that inflammatory cytokines (TFN-a, IL-1b) also enhanced the release of the MMPs from cultured rabbit keratocyte.We also confirmed inhibitory effects of superoxide dismutase (SOD) on polymorphonuclear leukocyte(PMN)-induced damage of corneal tissue in guinea pigs. The inhibitory effects of SOD were indicated that corneal damage may be induced by superoxide derived from infiltrating PMN as well as MMPs from keratocyte.