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Circannual Rhythms in the Effect of Neuroleptics

抗精神病药物作用的周期性节律

基本信息

批准号：
09670998
负责人：
NAGAYAMA Haruo
金额：
$ 1.92万
依托单位：
Oita Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

1) In order to elucidate whether circadian and circannual rhythms exist in the effect of 8-OH-DPAT,8-OH-DPAT was administered subcutaneously to male Wistar rats at different hours of the day in different seasons, and the 5-HT syndrome was quantified by recording the total frequency of forepaw treading and head weaving for a total of 90 mm. Each rat was used only once. The experiments were repeated five time at three-month intervals.2) Both forepaw treading and head weaving exhibited a significant circadian rhythm in every month examined.3) Both forepaw treading and head weaving exhibited a significant annual rhythm at all time points tested. The phases of the circadian rhythm exhibit one year period variations while those of the annual rhythm exhibit one day period variations. The annual rhythm in the responsiveness to 8-OH-DPAT was confirmed in animals that were kept under constant environmental conditions of the same temperature and the same light-dark period through successive generations. Taking this into account, it is strongly suggested that this is not a phenomenon based on direct reaction to either the photoperiodicity or seasonal change in the environmental temperature, but this is an endogenous circannual rhythm.4) The results suggest that both circadian and circannual rhythms exist in the responsiveness to the drug.5) Next, the rhythm in the responsiveness to 8-OH-DPAT was examined by observing hypothermia, another index of the 5-HIIA receptor function. The parameters of assessing the hypothermic response displayed significant circadian and circannual rhythms.6) Circannual rhythm in the effect of haloperidol is being examined by observing sedative effects in rats.

1)为了阐明8-OH-DPAT的作用是否存在昼夜节律和昼夜节律，在不同季节、一天中的不同时间对雄性Wistar大鼠皮下注射8-OH-DPAT，通过记录前爪踩踏和头部摆动的总频率来量化5-HT综合征，总共90 mm。每只大鼠仅使用一次。结果表明：（1）前爪踩踏和头摆动在每个月均表现出明显的昼夜节律;（2）前爪踩踏和头摆动在每个时间点均表现出明显的年节律。昼夜节律的相位呈现一年周期变化，而年节律的相位呈现一天周期变化。在连续几代保持在相同温度和相同光暗期的恒定环境条件下的动物中，证实了对8-OH-DPAT的反应性的年度节律。考虑到这一点，强烈建议这不是基于光周期性或环境温度的季节变化的直接反应的现象，而是内源性的昼夜节律。4）结果表明，昼夜节律和昼夜节律都存在于对药物的反应中。5）接下来，通过观察低温来检查对8-OH-DPAT的反应的节律，5-HIIA受体功能的另一个指标。评价低温反应的参数显示出明显的昼夜节律和年节律。6）通过观察大鼠的镇静作用来检查氟哌啶醇作用的年节律。