Intracellular signal-transduction in oxidized LDL-induced macrophage growth in arterial wall.
Intracellular signal-transduction in oxidized LDL-induced macrophage growth in arterial wall.
批准号:
09671065
负责人:
SHICHIRI Motoaki
金额:
$1.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1998
中文摘要
点击翻译按钮获取中文摘要
英文摘要
In this project, we demonstrated following findings ;(1) Endocytic uptake of lysophosphatidylcholine through the scavenger receptor A-I/A-II plays an essential role in oxidized LDL-induced macrophage proliferation.(2) Rise in intracellular calcium and subsequent activation of protein kinase C by oxidized LDL are involved in oxidized LDL-induced macrophageproliferation.(3) Induction of GM-CSF by oxidized LDL induces macrophage proliferation in autocrine or paracrine fashion.(4) HMG-CoA reductase inhibitors inhibit oxidized LDL-induced macrophage proliferation.(5) Glucocorticoids suppress oxidized LDL-induced macrophage proliferation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Matsumura T. et al.: "Two intracellular signaling pathways for activation of protein kinase C are involved in oxidized low-density lipoprotein-induced macrophage growth" Arterioscler Thromb Vasc Biol. 17. 3013-3020 (1997)
Matsumura T. 等人:“蛋白激酶 C 激活的两条细胞内信号传导途径参与氧化低密度脂蛋白诱导的巨噬细胞生长”Arterioscler Thromb Vasc Biol。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Yano T. et al.: "β-very low density lipoprotein induces triglyceride accumlation through receptor mediated endocytic pathway in 3T3-L1 adipocytes" Atherosclerosis. 135. 57-64 (1997)
Yano T.等人:“β-极低密度脂蛋白通过受体介导的内吞途径在3T3-L1脂肪细胞中诱导甘油三酯积累”动脉粥样硬化。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Sakai M.et al.: "Endocytosed lysophosphatidylcholine, through the scavenger receptor, plays an essential role in oxidized low-density lipoprotein-induced macrophage proliferation" Trends Cardiovasc Med. 8. 119-124 (1998)
Sakai M.等人:“通过清道夫受体内吞溶血磷脂酰胆碱,在氧化低密度脂蛋白诱导的巨噬细胞增殖中发挥重要作用”Trends Cardiovasc Med。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Anami Y. et al.: "Human β-migrating very low density lipoprotein induces foam cell formation in human mesangial cells." Atherosclerosis. 135. 225-234 (1997)
Anami Y. 等人:“人类 β 迁移极低密度脂蛋白诱导人类系膜细胞形成泡沫细胞。”135. 225-234 (1997)
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Yano, T.: "β-very low density lipoprotein induces Triglyceride-accumulation through receptor-mediated endocytic pathway in 3Tз-L1 adipocytes" Atherosclerosis. 135. 57-64 (1997)
Yano, T.:“β-极低密度脂蛋白通过 3Tз-L1 脂肪细胞中受体介导的内吞途径诱导甘油三酯积累”,动脉粥样硬化。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 27 条
IMPLICATION OF INSULIN GENE-THERAPY SYSTEM IN DIABETES TREATMENT : CONSTRUCTION OF BIO-ARITFICIAL PANCREATIC B CELL
-
批准号:06557061
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$9.73万
-
财政年份:1994
-
负责人:SHICHIRI Motoaki
-
依托单位:
Non-invasive blood glucose measurement using infrared absorption spectroscopy with a CO_2 laser - design for miniaturization
-
批准号:03557119
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$11.14万
-
财政年份:1991
-
负责人:SHICHIRI Motoaki
-
依托单位:
Development of non-invasive blood glucose measurement system : Application of laser absorption spectroscopy with an ATR prism
-
批准号:62870048
-
项目类别:Grant-in-Aid for Developmental Scientific Research
-
资助金额:$10.88万
-
财政年份:1987
-
负责人:SHICHIRI Motoaki
-
依托单位:
国内基金
海外基金
AS早期病变Foam Cell形成中ACAT基因的表达与调控
-
批准号:30170459
-
项目类别:面上项目
-
资助金额:20.0万元
-
批准年份:2001
-
负责人:李伯良
-
依托单位: