“L-form” bacteria: basic science, antibiotics, evolution and biotechnology

L 型细菌：基础科学、抗生素、进化和生物技术

• 批准号: FL210100071
• 负责人: Prof Jeffery Errington
• 金额: $ 227.06万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL210100071
• 关键词: form; bacteria; basic; science; antibiotics

This Fellowship addresses key gaps in knowledge about cell wall deficient bacteria called L-forms: an altered state of bacteria with intriguing properties both structurally and functionally. The main aims of the research program are to improve our understanding of the basic biology of L-forms and employ them as tools in several important ways: for understanding the mechanisms of cell wall synthesis and how antibiotics work, as models for early steps in the evolution of cellular life, and as a significant new platform for the production of proteins and fine chemicals. Outcomes and benefits include improved understanding of how to generate new antibiotics, and the development of new platforms for Australian biotechnology and biocommerce.

该奖学金解决了有关细胞壁缺陷细菌的关键知识空白，称为L形式：一种具有有趣结构和功能特性的细菌的改变状态。该研究计划的主要目的是提高我们对L型的基本生物学的了解，并在几个重要方面将其用作工具：了解细胞壁合成的机制和抗生素如何起作用，作为细胞生命进化早期步骤的模型，以及作为生产蛋白质和精细化学品的重要新平台。成果和好处包括更好地了解如何生产新的抗生素，以及为澳大利亚生物技术和生物商业开发新的平台。