What kind of neural circuit in the brain of prenatally stressed offspring may be responsible to the vulnerabill to chronic stress in adulthood

产前应激后代大脑中的哪种神经回路可能导致其成年后容易遭受慢性应激

基本信息

批准号：
09670975
负责人：
MIKUNI Masahiko
金额：
$ 2.05万
依托单位：
Gunma University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670975/
关键词：
prenaral stress animal model vulnerability neuronal plasiticity septum hypothalomo-pituitary-adrenal axis

项目摘要

It has been suggested that early adverse life events including childhood abuse, neglect, and parental loss may predispose individuals for the development of affective disorders in response to extreme stress exposure in adulthood. Recently, we have demonstrated that the prenatal saline injection stress produced an enhanced adrenocortical response to conditioned fear stress and a prolonged immobility duration in forced swimming stress, indicating that the prenatally stressed offspring seemed to be susceptive to an acute stress in adulthood endocrinologically and behaviorally. It is still unclear whether prenatally stressed rats can habituate to chronic stress in adulthood. We have investigated the stress response of c-fos mRNA expression in brain and of corticosterone secretion in prenatally stressed adult male rats during 14 days repeated restraint stress. To an acute restraint stress, prenatally stressed rats showed significantly increased response of c-fos mRNA expression, to the same extent, compared to control rats, in brain regions including para-ventricular nucleus, amygdala, locus ceruleus, raphe nucleus, cingulate cortex, piriform cortex, and seputum. Repeated restraint stress for 14 days induced significant reduction of c-fos response, compared to the expession of c-fos mRNA during acute restraint stress, in all investigated brain regions except septum of prenatally stressed rats. In septum, prenatally stressed rats showed significant increase in c-fos expression in response to repeated restraint stress, compared to control rats. In addition, control rats showed reduction of plasma corticosterone level at 120min after the beginning of restraint stress from the 7th day of stress, whereas prenatally stressed rats did not show such habituation. These findings indicate that the neural circuit including septum may be responsible to the vulnerabillty of prenatally stressed rats to chronic stress in adulthood.

有人提出，早期的不良生活事件，包括儿童虐待，忽视和父母损失，可能会使个人倾向于发展情感障碍，以应对成年后极端的压力暴露。最近，我们已经证明，产前盐水注射胁迫对有条件的恐惧压力产生了增强的肾上腺皮质反应，并且在强迫游泳压力下的持续时间延长，这表明产前压力后代似乎敏锐地对养育性的急性压力敏感。目前尚不清楚产前压力的大鼠是否可以习惯成年后的慢性压力。我们已经调查了14天重复约束应激的成年雄性大鼠在大脑和皮质酮分泌中C-FOS mRNA表达的应力反应。对于急性约束应激，与对照大鼠相比，在脑部区域中，c-fos mRNA表达的反应显着增加，包括脑室核，杏仁核，杏仁核，raphe ceruleus，raphe nucleus，raphe核，扣带皮质，皮质皮层和塞术。与在急性约束应力期间的C-FOS mRNA相比，在所有研究的大脑区域中，反复的约束应力诱导了C-FOS反应的显着降低，除了产前压力大鼠的隔膜以外。在隔膜中，与对照大鼠相比，产前压力大鼠在反复约束应力中显示出C-FOS表达的显着增加。此外，对照大鼠在胁迫第七天的约束应力开始后120分钟的血浆皮质酮水平降低，而产前压力的大鼠没有显示出这种习惯。这些发现表明，包括隔膜在内的神经回路可能是导致产前压力大鼠在成年期间遭受慢性应激的脆弱性的原因。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

三国雅彦: "発達期のストレスと神経系の可塑性並びに感情障害脆弱性" 医事新報. 3815. 105 (1997)

三国正彦：“发育压力、神经系统可塑性和情绪障碍脆弱性”Iji Shinpo 3815. 105 (1997)。

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