Neuropathological studies on the vulnerability to mood disorders and refractoriness to antidepressant treatment.

关于情绪障碍易感性和抗抑郁治疗无效的神经病理学研究。

• 批准号: 14570909
• 负责人: MIKUNI Masahiko
• 金额: $ 2.24万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570909/
• 关键词: mood disorder; 18F-FDG-PET; DEX; CRH test; pre-frontal cortex; superior temporal gyrus; para-hippocampal gyrus; vulnerability; postmortem brain; 左前前頭前野; 感情障害; 発症脆弱性; 死後脳; 脳画像; セロトニン2-A; 受容体; 左前頭前野; 右上側頭回; 紡錘状回; FDG-PET脳画像

To clarify a neuronal vulnerability in primary mood disorder, we have investigated if cytoarchitectural alterations would be observed in the left prefrontal cortex, BA 9 in postmortem brain tissue from subjects with primary mood disorder, who were under long-term treatment with antidepressant and mood stabilizers. The left prefrontal cortex, BA 9 is documented to be one of the pathophysiological brain regions, and we have clearly demonstrated that the lowered glucose uptake activity was estimated by FDG-PET, in the left prefrontal cortex, BA 9, in depressive state-depended manner. Reduction in the density of small cell neurons has been observed in layer II, but not in I, III, IV in the left BA 9. There are no changes in glial density and large neuronal cell density in the left BA 9, although the decrease was observed through the depth of cortex of BA 9, compared with normal controls. Interestingly, the number of serotonin (5-HT)-2A receptor immunorecative cells was significantly increased in layer II, but not in I, III, IV in the left BA 9 in postmortem brain from subjects with primary mood disorder. The density of 5-HT-2A receptor binding sites is well-known to be down-regulated after subchronic administration of antidepressant agents in rat cerebral cortex. Therefore, the layer II in the left prefrontal cortex, BA 9 is of special interest in the vulnerability in primary mood disorder and refractoriness to antidepressant treatment.

为了阐明原发性情绪障碍中的神经元脆弱性，我们研究了是否在左前前额叶皮层中观察到细胞结构改变，而在现年脑组织的左前前额叶皮质中，BA 9在抗抑郁药和情绪稳定剂中长期治疗。左前额叶皮层，BA 9被记录为病理生理学大脑区域之一，我们清楚地证明，降低的葡萄糖摄取活性是由FDG-PET估算出的，在左前额叶皮层BA 9中，以抑郁状态抑制状态抑制方式。在II层中已经观察到小细胞神经元密度的降低，但在左BA 9中的I，III，IV中没有观察到。与正常对照相比，左BA 9中的神经胶质密度和较大的神经元细胞密度没有变化，尽管通过BA 9的皮质深度观察到了降低。有趣的是，II层中5-羟色胺（5-HT）-2A受体免疫药物的数量显着增加，但在III，III，IV中，III，IV在左BA 9中的左BA 9中均来自现有情绪障碍受试者的死后大脑中。 5-HT-2A受体结合位点的密度众所周知，在大鼠脑皮质中亚慢性施用抗抑郁药后，众所周知被下调。因此，在左前额叶皮层中的II层BA 9在原发性情绪障碍和抗抑郁药治疗的脆弱性方面特别感兴趣。

项目成果

Toru Uehara, Kazuo Takeuchi, Ichiro Ohmori, Yoshiaki Kawashima, Masahiro Goto, Masahiko Mikuni, Walter Vandereycken: "Factor analytic study of the Anorectic Behavior Observation Scale (ABOS) in Japan : comparisons with the original Belgian study"Psychiatr

Toru Uehara、Kazuo Takeuchi、Ichiro Ohmori、Yoshiaki Kawashima、Masahiro Goto、Masahiko Mikuni、Walter Vandereycken：“日本厌食行为观察量表 (ABOS) 的因素分析研究：与原始比利时研究的比较”Psychiatr

三國 雅彦: "統合失調症治療ガイドライン 精神医学講座担当者会議監修 佐藤光源、井上新平編"医学書院. 180-186 (2004)

三国正彦：“精神分裂症治疗指南，由精神病学课程督导会议监督，佐藤光和井上新平编辑”Igakushoin 180-186（2004）。

Mikuni M, Kitera K, Muneoka K, Saitoh K, Yamazaki C, Majima T, Ida I, Watanabe Y: "Relationship between Vulnerability of Major Depressive Disorder and Prenatal Stress or Glucocorticoid Treatment. In : Recent Advances in the Research of Affective Disorder

Mikuni M、Kitera K、Muneoka K、Saitoh K、Yamazaki C、Majima T、Ida I、Watanabe Y：“重度抑郁症的脆弱性与产前应激或糖皮质激素治疗之间的关系。在：情感障碍研究的最新进展

三國 雅彦: "発症脆弱性の脳機能・器質因子"Clinical Neuroscience. 22. 147-150 (2004)

Masahiko Mikuni：“导致发育脆弱性的脑功能和有机因素”《临床神经科学》22. 147-150 (2004)。

Uehara T, Ohmori T, Goto M, Kawashima Y, Moro H, Fukuda M, Mikuni M: "Eating disorders and family functioning - Relationships with diagnostic classifications, symptoms, and outocomes. In : Focus on Eating Disorders Research, edited by Pamela I.Swain"Nova

Uehara T、Ohmori T、Goto M、Kawashima Y、Moro H、Fukuda M、Mikuni M：“饮食失调和家庭功能 - 与诊断分类、症状和结果的关系。见：聚焦饮食失调研究，由 Pamela I 编辑