Neuroscientific Investigation of the Pathophysiology of Mood Disorder and Suicide Behavior

情绪障碍和自杀行为病理生理学的神经科学研究

基本信息

批准号：
11470200
负责人：
MIKUNI Masahiko
金额：
$ 9.6万
依托单位：
Gunma University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

项目摘要

We have investigated disorder-specific pathophysiology of mood disorder, including suicide behavior, by using ^<18>F-FDG-Positron Emission Tomography (PET) and combined endocrinological examination of dexamethasone (DEX) and corticotropin-releasing hormone (CRH). Drug-naive 24 patients with major depression and 10 patients who were investigated by brain imaging analysis and neuroendocrinological examination at pre-treatment and at post-treatment when they were well responded to antidepressant treatment, are included in this study. 75 % of 24 mood disorder patients were non-suppressor in DEX/CRH examination, who have had more frequently the past history of suicide attempt than suppressor. After recovery from depression, most of non-suppressors were changed to suppressors, but 20 % of mood disorders were still non-suppressor, suggesting that some parts of non-suppressor are trait marker of mood disorder or susceptive factor of mood disorder.On the other hand, ^<18>F-FDG-PET study has reveal that left pre-frontal cortex and right superior temporal gyrus of mood disorder patients are significantly decreased to take up ^<18>F-FDG than healthy controls, whereas para-hippocampal gyrus is increased in ^<18>F-FDG intake. These pathological alterations during depressive phase were normalized after recovery from depression, except right superior temporal gyrus. In addition, SPM analysis has clearly demonstrated that ^<18>F-FDG intake into right para-hippocampal gyrus was smaller in non-suppressor than in suppressor. Further studies are needed to clarify the histological alterations in left pre-frontal cortex, right superior temporal gyrus, and right para-hippocampal gyrus from postmortem brain of mood disorder.

我们通过使用 ^<18> f-fdg-PosItron发射断层扫描（PET）和对地塞米松（DEX）和皮质激素 - 释放激素（CRH）的内分泌学检查，研究了情绪障碍的疾病特异性病理生理，包括自杀行为，包括自杀行为。这项研究包括在治疗前和治疗后对脑成像分析和神经内分泌学检查进行调查的24例严重抑郁症患者，并在治疗后对抗抑郁药的反应后进行了调查。在24名情绪障碍患者中，有75％是DEX/CRH检查中的非抑制剂，他们比抑制剂更频繁地自杀率。从抑郁症中康复后，大多数非抑制剂被更改为抑制剂，但是20％的情绪障碍仍然是非抑制剂，这表明非抑制剂的某些部分是情绪障碍的特质标记或情绪障碍的特征标记。另一方面，情绪障碍。在另一方面， ^<18> fdg-pet的研究表明，左上是右上的较高的较高的较高的较高的较高的情绪，使得右上是右上的情绪。 ^<18> f-fdg比健康对照组，而para-Hampocampal回合在 ^<18> F-FDG摄入量中增加。除了右上颞回恢复后，抑郁阶段恢复后的这些病理变化是标准化的。此外，SPM分析清楚地表明，在非抑制剂中， ^<18> F-FDG摄入右para-Hampocampal回合的摄入量小于抑制剂。需要进一步的研究来阐明左额叶皮层的组织学改变，右颞回和右Para-Hampocampal Gyrus，来自情绪障碍后大脑。